The causes and consequences of genetic heterogeneity in cancer evolution.
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| Title: | The causes and consequences of genetic heterogeneity in cancer evolution. |
|---|---|
| Authors: | Burrell, Rebecca A., McGranahan, Nicholas, Bartek, Jiri, Swanton, Charles |
| Source: | Nature. 9/19/2013, Vol. 501 Issue 7467, p338-345. 8p. 1 Diagram, 1 Chart. |
| Subjects: | Genes, Diversity & Accommodation (Book), Tumors, Cancer, Plethora (Pathology), Evolutionary theories |
| Abstract: | Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 90310323 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The causes and consequences of genetic heterogeneity in cancer evolution. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burrell%2C+Rebecca+A%2E%22">Burrell, Rebecca A.</searchLink><br /><searchLink fieldCode="AR" term="%22McGranahan%2C+Nicholas%22">McGranahan, Nicholas</searchLink><br /><searchLink fieldCode="AR" term="%22Bartek%2C+Jiri%22">Bartek, Jiri</searchLink><br /><searchLink fieldCode="AR" term="%22Swanton%2C+Charles%22">Swanton, Charles</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 9/19/2013, Vol. 501 Issue 7467, p338-345. 8p. 1 Diagram, 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Diversity+%26+Accommodation+%28Book%29%22">Diversity & Accommodation (Book)</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Plethora+%28Pathology%29%22">Plethora (Pathology)</searchLink><br /><searchLink fieldCode="DE" term="%22Evolutionary+theories%22">Evolutionary theories</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=90310323 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature12625 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 338 Subjects: – SubjectFull: Genes Type: general – SubjectFull: Diversity & Accommodation (Book) Type: general – SubjectFull: Tumors Type: general – SubjectFull: Cancer Type: general – SubjectFull: Plethora (Pathology) Type: general – SubjectFull: Evolutionary theories Type: general Titles: – TitleFull: The causes and consequences of genetic heterogeneity in cancer evolution. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burrell, Rebecca A. – PersonEntity: Name: NameFull: McGranahan, Nicholas – PersonEntity: Name: NameFull: Bartek, Jiri – PersonEntity: Name: NameFull: Swanton, Charles IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 09 Text: 9/19/2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 501 – Type: issue Value: 7467 Titles: – TitleFull: Nature Type: main |
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