Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.
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| Title: | Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients. |
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| Authors: | Martínez ‐ Martín, P., Rodríguez ‐ Blázquez, C., Forjaz, M. J., Álvarez ‐ Sánchez, M., Arakaki, T., Bergareche ‐ Yarza, A., Chade, A., Garretto, N., Gershanik, O., Kurtis, M. M., Martínez ‐ Castrillo, J. C., Mendoza ‐ Rodríguez, A., Moore, H. P., Rodríguez ‐ Violante, M., Singer, C., Tilley, B. C., Huang, J., Stebbins, G. T., Goetz, C. G. |
| Source: | European Journal of Neurology. Mar2014, Vol. 21 Issue 3, p519-524. 6p. 4 Charts. |
| Subjects: | Parkinson's disease patients, Health status indicators, Exploratory factor analysis, Regression analysis, Cross-sectional method, Movement disorders |
| Abstract: | Background and purpose The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale ( MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease ( PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life ( HRQo L) evaluations in PD patients. Methods An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5 D and PD Questionnaire − eight items ( PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5 D and PDQ-8) were performed. Results The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5 D index and the MDS-UPDRS ranged from −0.46 (Part IV) to −0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5 D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, n M- EDL and fluctuations was the main determinant for both the EQ-5 D and PDQ-8 indexes. Conclusions The MDS- UPDRS component most tightly related with the HRQo L measures was a combination of motor and non-motor experiences of daily living. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background and purpose The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale ( MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease ( PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life ( HRQo L) evaluations in PD patients. Methods An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5 D and PD Questionnaire − eight items ( PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5 D and PDQ-8) were performed. Results The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5 D index and the MDS-UPDRS ranged from −0.46 (Part IV) to −0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5 D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, n M- EDL and fluctuations was the main determinant for both the EQ-5 D and PDQ-8 indexes. Conclusions The MDS- UPDRS component most tightly related with the HRQo L measures was a combination of motor and non-motor experiences of daily living. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13515101 |
| DOI: | 10.1111/ene.12349 |
