View in EDS HTML Full Text PDF Full Text

Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.

Saved in:
Bibliographic Details
Title: Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.
Authors: Martínez ‐ Martín, P., Rodríguez ‐ Blázquez, C., Forjaz, M. J., Álvarez ‐ Sánchez, M., Arakaki, T., Bergareche ‐ Yarza, A., Chade, A., Garretto, N., Gershanik, O., Kurtis, M. M., Martínez ‐ Castrillo, J. C., Mendoza ‐ Rodríguez, A., Moore, H. P., Rodríguez ‐ Violante, M., Singer, C., Tilley, B. C., Huang, J., Stebbins, G. T., Goetz, C. G.
Source: European Journal of Neurology. Mar2014, Vol. 21 Issue 3, p519-524. 6p. 4 Charts.
Subjects: Parkinson's disease patients, Health status indicators, Exploratory factor analysis, Regression analysis, Cross-sectional method, Movement disorders
Abstract: Background and purpose The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale ( MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease ( PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life ( HRQo L) evaluations in PD patients. Methods An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5 D and PD Questionnaire − eight items ( PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5 D and PDQ-8) were performed. Results The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5 D index and the MDS-UPDRS ranged from −0.46 (Part IV) to −0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5 D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, n M- EDL and fluctuations was the main determinant for both the EQ-5 D and PDQ-8 indexes. Conclusions The MDS- UPDRS component most tightly related with the HRQo L measures was a combination of motor and non-motor experiences of daily living. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 94379067
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Martínez+‐+Martín%2C+P%2E%22">Martínez ‐ Martín, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Rodríguez+‐+Blázquez%2C+C%2E%22">Rodríguez ‐ Blázquez, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Forjaz%2C+M%2E+J%2E%22">Forjaz, M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Álvarez+‐+Sánchez%2C+M%2E%22">Álvarez ‐ Sánchez, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Arakaki%2C+T%2E%22">Arakaki, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Bergareche+‐+Yarza%2C+A%2E%22">Bergareche ‐ Yarza, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Chade%2C+A%2E%22">Chade, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Garretto%2C+N%2E%22">Garretto, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Gershanik%2C+O%2E%22">Gershanik, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Kurtis%2C+M%2E+M%2E%22">Kurtis, M. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Martínez+‐+Castrillo%2C+J%2E+C%2E%22">Martínez ‐ Castrillo, J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Mendoza+‐+Rodríguez%2C+A%2E%22">Mendoza ‐ Rodríguez, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Moore%2C+H%2E+P%2E%22">Moore, H. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Rodríguez+‐+Violante%2C+M%2E%22">Rodríguez ‐ Violante, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Singer%2C+C%2E%22">Singer, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Tilley%2C+B%2E+C%2E%22">Tilley, B. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+J%2E%22">Huang, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Stebbins%2C+G%2E+T%2E%22">Stebbins, G. T.</searchLink><br /><searchLink fieldCode="AR" term="%22Goetz%2C+C%2E+G%2E%22">Goetz, C. G.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2014, Vol. 21 Issue 3, p519-524. 6p. 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease+patients%22">Parkinson's disease patients</searchLink><br /><searchLink fieldCode="DE" term="%22Health+status+indicators%22">Health status indicators</searchLink><br /><searchLink fieldCode="DE" term="%22Exploratory+factor+analysis%22">Exploratory factor analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale ( MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease ( PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life ( HRQo L) evaluations in PD patients. Methods An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5 D and PD Questionnaire − eight items ( PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5 D and PDQ-8) were performed. Results The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5 D index and the MDS-UPDRS ranged from −0.46 (Part IV) to −0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5 D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, n M- EDL and fluctuations was the main determinant for both the EQ-5 D and PDQ-8 indexes. Conclusions The MDS- UPDRS component most tightly related with the HRQo L measures was a combination of motor and non-motor experiences of daily living. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=94379067
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.12349
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 519
    Subjects:
      – SubjectFull: Parkinson's disease patients
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Exploratory factor analysis
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Movement disorders
        Type: general
    Titles:
      – TitleFull: Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Martínez ‐ Martín, P.
      – PersonEntity:
          Name:
            NameFull: Rodríguez ‐ Blázquez, C.
      – PersonEntity:
          Name:
            NameFull: Forjaz, M. J.
      – PersonEntity:
          Name:
            NameFull: Álvarez ‐ Sánchez, M.
      – PersonEntity:
          Name:
            NameFull: Arakaki, T.
      – PersonEntity:
          Name:
            NameFull: Bergareche ‐ Yarza, A.
      – PersonEntity:
          Name:
            NameFull: Chade, A.
      – PersonEntity:
          Name:
            NameFull: Garretto, N.
      – PersonEntity:
          Name:
            NameFull: Gershanik, O.
      – PersonEntity:
          Name:
            NameFull: Kurtis, M. M.
      – PersonEntity:
          Name:
            NameFull: Martínez ‐ Castrillo, J. C.
      – PersonEntity:
          Name:
            NameFull: Mendoza ‐ Rodríguez, A.
      – PersonEntity:
          Name:
            NameFull: Moore, H. P.
      – PersonEntity:
          Name:
            NameFull: Rodríguez ‐ Violante, M.
      – PersonEntity:
          Name:
            NameFull: Singer, C.
      – PersonEntity:
          Name:
            NameFull: Tilley, B. C.
      – PersonEntity:
          Name:
            NameFull: Huang, J.
      – PersonEntity:
          Name:
            NameFull: Stebbins, G. T.
      – PersonEntity:
          Name:
            NameFull: Goetz, C. G.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2014
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 21
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1