Bibliographic Details
| Title: |
Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease. |
| Authors: |
Ross, G. W., O'Callaghan, J. P., Sharp, D. S., Petrovitch, H., Miller, D. B., Abbott, R. D., Nelson, J., Launer, L. J., Foley, D. J., Burchfiel, C. M., Hardman, J., White, L. R. |
| Source: |
Acta Neurologica Scandinavica. May2003, Vol. 107 Issue 5, p318-323. 6p. |
| Subjects: |
Alzheimer's disease, Enzyme-linked immunosorbent assay, Temporal lobe, Parietal lobe, Forensic medicine, Brain |
| Abstract: |
Objectives – Our objectives were to quantify glial fibrillary acidic protein (GFAP) in brains of Alzheimer's disease (AD) cases, and non-AD controls to determine the regions with the most severe gliosis in AD. Material and methods – In a case–control design, we used an enzyme-linked immunosorbent assay (ELISA) to quantify GFAP in frozen brain from four areas of neocortex in 10 AD cases, 10 age-matched controls, and 10 younger controls from the Honolulu-Asia Aging Study autopsy archive. Results – Median age at death was 83.5 years for cases and age-matched controls, and 77 years for younger controls. For the AD cases compared with the age-matched controls, levels of GFAP in occipital (P =0.01), parietal (P =0.028), and temporal lobes (P =0.004) (but not frontal) were significantly higher in the cases. The median GFAP excess in AD cases compared with age matched controls was highest in the temporal lobe. Conclusions – Regional quantification of GFAP reveals that the glial response is most prominent in the temporal lobe in AD. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
