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Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease.

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Title: Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease.
Authors: Ross, G. W., O'Callaghan, J. P., Sharp, D. S., Petrovitch, H., Miller, D. B., Abbott, R. D., Nelson, J., Launer, L. J., Foley, D. J., Burchfiel, C. M., Hardman, J., White, L. R.
Source: Acta Neurologica Scandinavica. May2003, Vol. 107 Issue 5, p318-323. 6p.
Subjects: Alzheimer's disease, Enzyme-linked immunosorbent assay, Temporal lobe, Parietal lobe, Forensic medicine, Brain
Abstract: Objectives – Our objectives were to quantify glial fibrillary acidic protein (GFAP) in brains of Alzheimer's disease (AD) cases, and non-AD controls to determine the regions with the most severe gliosis in AD. Material and methods – In a case–control design, we used an enzyme-linked immunosorbent assay (ELISA) to quantify GFAP in frozen brain from four areas of neocortex in 10 AD cases, 10 age-matched controls, and 10 younger controls from the Honolulu-Asia Aging Study autopsy archive. Results – Median age at death was 83.5 years for cases and age-matched controls, and 77 years for younger controls. For the AD cases compared with the age-matched controls, levels of GFAP in occipital (P =0.01), parietal (P =0.028), and temporal lobes (P =0.004) (but not frontal) were significantly higher in the cases. The median GFAP excess in AD cases compared with age matched controls was highest in the temporal lobe. Conclusions – Regional quantification of GFAP reveals that the glial response is most prominent in the temporal lobe in AD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease.
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  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Parietal+lobe%22">Parietal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Forensic+medicine%22">Forensic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink>
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  Data: Objectives – Our objectives were to quantify glial fibrillary acidic protein (GFAP) in brains of Alzheimer's disease (AD) cases, and non-AD controls to determine the regions with the most severe gliosis in AD. Material and methods – In a case–control design, we used an enzyme-linked immunosorbent assay (ELISA) to quantify GFAP in frozen brain from four areas of neocortex in 10 AD cases, 10 age-matched controls, and 10 younger controls from the Honolulu-Asia Aging Study autopsy archive. Results – Median age at death was 83.5 years for cases and age-matched controls, and 77 years for younger controls. For the AD cases compared with the age-matched controls, levels of GFAP in occipital (P =0.01), parietal (P =0.028), and temporal lobes (P =0.004) (but not frontal) were significantly higher in the cases. The median GFAP excess in AD cases compared with age matched controls was highest in the temporal lobe. Conclusions – Regional quantification of GFAP reveals that the glial response is most prominent in the temporal lobe in AD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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