Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory.
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| Title: | Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory. |
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| Authors: | Sumner, Jennifer A. (AUTHOR), Vrshek-Schallhorn, Suzanne (AUTHOR), Mineka, Susan (AUTHOR), Zinbarg, Richard E. (AUTHOR), Craske, Michelle G. (AUTHOR), Redei, Eva E. (AUTHOR), Wolitzky-Taylor, Kate (AUTHOR), Adam, Emma K. (AUTHOR) |
| Source: | Cognition & Emotion. Aug2014, Vol. 28 Issue 5, p947-958. 12p. |
| Subjects: | Serotonin transporters, Genetic polymorphisms, Mental depression, Autobiographical memory, Cognition, Longitudinal method |
| Abstract: | Overgeneral autobiographical memory (OGM) is a key memory deficit in major depressive disorder (MDD). Much research has examined cognitive mechanisms underlying OGM, but little work has investigated potential neurobiological influences. There is preliminary evidence that a genetic serotonergic vulnerability coupled with depressive symptoms may be associated with other memory impairments, and experimental research suggests a role for serotonin in OGM. We investigated whether a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was associated with OGM in interaction with a lifetime history of MDD in 370 young adults in a longitudinal study of risk for emotional disorders. There was a significant interaction between 5-HTTLPR genotype and lifetime history of MDD in predicting OGM. AmongSallele homozygotes, MDD history was associated with greater OGM, whereas no significant relationship between MDD history and OGM emerged amongLcarriers. Furthermore, there was evidence that a greater number ofSalleles were associated with greater memory specificity in individuals without a history of MDD. Implications for understanding cognitive and biological risk for depression are discussed. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Overgeneral autobiographical memory (OGM) is a key memory deficit in major depressive disorder (MDD). Much research has examined cognitive mechanisms underlying OGM, but little work has investigated potential neurobiological influences. There is preliminary evidence that a genetic serotonergic vulnerability coupled with depressive symptoms may be associated with other memory impairments, and experimental research suggests a role for serotonin in OGM. We investigated whether a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was associated with OGM in interaction with a lifetime history of MDD in 370 young adults in a longitudinal study of risk for emotional disorders. There was a significant interaction between 5-HTTLPR genotype and lifetime history of MDD in predicting OGM. AmongSallele homozygotes, MDD history was associated with greater OGM, whereas no significant relationship between MDD history and OGM emerged amongLcarriers. Furthermore, there was evidence that a greater number ofSalleles were associated with greater memory specificity in individuals without a history of MDD. Implications for understanding cognitive and biological risk for depression are discussed. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 02699931 |
| DOI: | 10.1080/02699931.2013.865596 |
