Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder.
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| Title: | Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder. |
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| Authors: | Kahl, K. G., Hueper, K., Schweiger, U., Gutberlet, M., Detlef, A.‐M., Weiss, C., Bohlen, A., Pul, R., Lichtinghagen, R., Wacker, F., Hartung, D. |
| Source: | Acta Psychiatrica Scandinavica. Aug2014, Vol. 130 Issue 2, p137-143. 7p. |
| Subjects: | Coronary artery abnormalities, Adipose tissue physiology, Mental illness & physiology, Health outcome assessment, Magnetic resonance imaging, Comorbidity, Diagnosis |
| Abstract: | Objective Major depressive disorder ( MDD) is associated with an increased risk for developing coronary artery disease (CAD). Recently, pericardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of CAD. Therefore, we investigated pericardial adipose tissue volumes in patients with MDD and compared them to healthy comparison subjects. Method In this case-control study at a university medical center, 50 male and female in-patients with MDD and 25 healthy men and women were examined. The main outcome measures were the volumes of pericardial adipose tissue, intra-abdominal adipose tissue (Ia AT) and subcutaneous adipose tissue (Sc AT) which were measured using magnetic resonance imaging. Results The pericardial adipose tissue volumes were greater in men and women with MDD compared with the healthy comparison group following adjustments for the effects of age, weight, height, and physical activity. Conclusion This study expands our knowledge about the alterations in body composition that occur in patients with MDD. The findings are highly relevant for understanding the comorbidity between heart disease and depressive disorders. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective Major depressive disorder ( MDD) is associated with an increased risk for developing coronary artery disease (CAD). Recently, pericardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of CAD. Therefore, we investigated pericardial adipose tissue volumes in patients with MDD and compared them to healthy comparison subjects. Method In this case-control study at a university medical center, 50 male and female in-patients with MDD and 25 healthy men and women were examined. The main outcome measures were the volumes of pericardial adipose tissue, intra-abdominal adipose tissue (Ia AT) and subcutaneous adipose tissue (Sc AT) which were measured using magnetic resonance imaging. Results The pericardial adipose tissue volumes were greater in men and women with MDD compared with the healthy comparison group following adjustments for the effects of age, weight, height, and physical activity. Conclusion This study expands our knowledge about the alterations in body composition that occur in patients with MDD. The findings are highly relevant for understanding the comorbidity between heart disease and depressive disorders. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0001690X |
| DOI: | 10.1111/acps.12242 |
