A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
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| Title: | A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. |
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| Authors: | Ariey, Frédéric, Witkowski, Benoit, Amaratunga, Chanaki, Beghain, Johann, Langlois, Anne-Claire, Khim, Nimol, Kim, Saorin, Duru, Valentine, Bouchier, Christiane, Ma, Laurence, Lim, Pharath, Leang, Rithea, Duong, Socheat, Sreng, Sokunthea, Suon, Seila, Chuor, Char Meng, Bout, Denis Mey, Ménard, Sandie, Rogers, William O., Genton, Blaise |
| Source: | Nature. 1/2/2014, Vol. 505 Issue 7481, p50-55. 6p. |
| Subjects: | Biomarkers, Artemisinin, Plasmodium falciparum, Drug resistance, Malaria prevention, Protozoa |
| Geographic Terms: | Southeast Asia |
| Abstract: | Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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