A complex iron-calcium cofactor catalyzing phosphotransfer chemistry.

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Bibliographic Details
Title:	A complex iron-calcium cofactor catalyzing phosphotransfer chemistry.
Authors:	Shee Chien Yong, Roversi, Pietro, Lillington, James, Rodriguez, Fernanda, Krehenbrink, Martin, Zeldin, Oliver B., Garman, Elspeth F., Lea, Susan M., Berks, Ben C.
Source:	Science (pre-March 2025). 9/5/2014, Vol. 345 Issue 6201, p1170-1173. 4p.
Subjects:	Alkaline phosphatase, Cofactors (Biochemistry), Molecular structure of metalloproteins, Phosphates, Enzymes
Abstract:	The article discusses research by the authors into the structure of the microbial alkaline phosphatase enzyme PhoX and its role in microorganisms' phosphate acquisition. Topics include the presence of an iron-calcium cofactor similar to certain metal complexes, details of the catalytic mechanism involved, and the possibility that microbial phosphate acquisition is limited by the bioavailability of iron.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	The article discusses research by the authors into the structure of the microbial alkaline phosphatase enzyme PhoX and its role in microorganisms' phosphate acquisition. Topics include the presence of an iron-calcium cofactor similar to certain metal complexes, details of the catalytic mechanism involved, and the possibility that microbial phosphate acquisition is limited by the bioavailability of iron.
ISSN:	00368075
DOI:	10.1126/science.1254237