Bibliographic Details
| Title: |
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. |
| Authors: |
Fowler, Benjamin J., Gelfand, Bradley D., Younghee Kim, Kerur, Nagaraj, Tarallo, Valeria, Yoshio Hirano, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Shengjian Li, Tetsuhiro Yasuma, Takeshi Mizutani, Reo Yasuma |
| Source: |
Science (pre-March 2025). 11/21/2014, Vol. 346 Issue 6212, p1000-1003. 4p. |
| Subjects: |
Nucleoside reverse transcriptase inhibitors, Inflammation prevention, Retinal degeneration, Enzyme inactivation, Caspase inhibitors, Adenosine triphosphate receptors, Anti-inflammatory agents, Therapeutics |
| Abstract: |
The article discusses research investigating the use of drugs to block HIV replication, called nucleoside reverse transcriptase inhibitors (NRTIs), in adenosine triphosphate receptor (ATP) P2X7-driven diseases, such as macular degeneration. The inhibition of P2X7-mediated NLRP3 inflammasome activation by NRTI and NRTI inactivation of the effector of the NLRP3 inflammasome, caspase-1, which is induced by the restriction endonuclease Alu RNA, are discussed. |
| Database: |
Psychology and Behavioral Sciences Collection |
