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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

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Title: Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
Authors: Fowler, Benjamin J., Gelfand, Bradley D., Younghee Kim, Kerur, Nagaraj, Tarallo, Valeria, Yoshio Hirano, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Shengjian Li, Tetsuhiro Yasuma, Takeshi Mizutani, Reo Yasuma
Source: Science (pre-March 2025). 11/21/2014, Vol. 346 Issue 6212, p1000-1003. 4p.
Subjects: Nucleoside reverse transcriptase inhibitors, Inflammation prevention, Retinal degeneration, Enzyme inactivation, Caspase inhibitors, Adenosine triphosphate receptors, Anti-inflammatory agents, Therapeutics
Abstract: The article discusses research investigating the use of drugs to block HIV replication, called nucleoside reverse transcriptase inhibitors (NRTIs), in adenosine triphosphate receptor (ATP) P2X7-driven diseases, such as macular degeneration. The inhibition of P2X7-mediated NLRP3 inflammasome activation by NRTI and NRTI inactivation of the effector of the NLRP3 inflammasome, caspase-1, which is induced by the restriction endonuclease Alu RNA, are discussed.
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 99576306
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
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  Data: <searchLink fieldCode="AR" term="%22Fowler%2C+Benjamin+J%2E%22">Fowler, Benjamin J.</searchLink><br /><searchLink fieldCode="AR" term="%22Gelfand%2C+Bradley+D%2E%22">Gelfand, Bradley D.</searchLink><br /><searchLink fieldCode="AR" term="%22Younghee+Kim%22">Younghee Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Kerur%2C+Nagaraj%22">Kerur, Nagaraj</searchLink><br /><searchLink fieldCode="AR" term="%22Tarallo%2C+Valeria%22">Tarallo, Valeria</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshio+Hirano%22">Yoshio Hirano</searchLink><br /><searchLink fieldCode="AR" term="%22Amarnath%2C+Shoba%22">Amarnath, Shoba</searchLink><br /><searchLink fieldCode="AR" term="%22Fowler%2C+Daniel+H%2E%22">Fowler, Daniel H.</searchLink><br /><searchLink fieldCode="AR" term="%22Radwan%2C+Marta%22">Radwan, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Mark+T%2E%22">Young, Mark T.</searchLink><br /><searchLink fieldCode="AR" term="%22Pittman%2C+Keir%22">Pittman, Keir</searchLink><br /><searchLink fieldCode="AR" term="%22Kubes%2C+Paul%22">Kubes, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Agarwal%2C+Hitesh+K%2E%22">Agarwal, Hitesh K.</searchLink><br /><searchLink fieldCode="AR" term="%22Parang%2C+Keykavous%22">Parang, Keykavous</searchLink><br /><searchLink fieldCode="AR" term="%22Hinton%2C+David+R%2E%22">Hinton, David R.</searchLink><br /><searchLink fieldCode="AR" term="%22Bastos-Carvalho%2C+Ana%22">Bastos-Carvalho, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22Shengjian+Li%22">Shengjian Li</searchLink><br /><searchLink fieldCode="AR" term="%22Tetsuhiro+Yasuma%22">Tetsuhiro Yasuma</searchLink><br /><searchLink fieldCode="AR" term="%22Takeshi+Mizutani%22">Takeshi Mizutani</searchLink><br /><searchLink fieldCode="AR" term="%22Reo+Yasuma%22">Reo Yasuma</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/21/2014, Vol. 346 Issue 6212, p1000-1003. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Nucleoside+reverse+transcriptase+inhibitors%22">Nucleoside reverse transcriptase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation+prevention%22">Inflammation prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+degeneration%22">Retinal degeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme+inactivation%22">Enzyme inactivation</searchLink><br /><searchLink fieldCode="DE" term="%22Caspase+inhibitors%22">Caspase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Adenosine+triphosphate+receptors%22">Adenosine triphosphate receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Label: Abstract
  Group: Ab
  Data: The article discusses research investigating the use of drugs to block HIV replication, called nucleoside reverse transcriptase inhibitors (NRTIs), in adenosine triphosphate receptor (ATP) P2X7-driven diseases, such as macular degeneration. The inhibition of P2X7-mediated NLRP3 inflammasome activation by NRTI and NRTI inactivation of the effector of the NLRP3 inflammasome, caspase-1, which is induced by the restriction endonuclease Alu RNA, are discussed.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=99576306
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        Value: 10.1126/science.1261754
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        Text: English
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        StartPage: 1000
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        Type: general
      – SubjectFull: Inflammation prevention
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      – SubjectFull: Retinal degeneration
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      – SubjectFull: Enzyme inactivation
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      – SubjectFull: Caspase inhibitors
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      – SubjectFull: Adenosine triphosphate receptors
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      – SubjectFull: Anti-inflammatory agents
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              Text: 11/21/2014
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