Antisense oligodeoxynucleotides to NMDA-Ri receptor channel protect cortical neurons from...
Saved in:
| Title: | Antisense oligodeoxynucleotides to NMDA-Ri receptor channel protect cortical neurons from... |
|---|---|
| Authors: | Wahlestedt, C., Golanov, E. |
| Source: | Nature. 5/20/1993, Vol. 363 Issue 6426, p260. 4p. 1 Diagram, 8 Graphs. |
| Subjects: | Nervous system |
| Abstract: | States that the excitatory amino acid, L-glutamate, acting through its N-methyl-D-aspartate (NMDA) receptor, may contribute to neuronal death following cerebral vascular occlusion. Demonstration that the inhibition of the synthesis of NMDA-R1 by treatment with antisense oligodeoxynucleotides selectively reduces the expression of NMDA receptors; Reduction of the volume of focal ischemic infarction produced by occlusion of the middle cerebral artery in the rat. |
| Database: | Engineering Source |
Be the first to leave a comment!
