ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility.
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| Title: | ABBV-712-induced cardiac pathology in rats is related to off-target-driven acute vasodilation, tachycardia, and increased cardiac contractility. |
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| Authors: | Kohnken, Rebecca1 (AUTHOR), Fossey, Stacey2 (AUTHOR), Buck, Wayne R2 (AUTHOR), Segreti, Jason1 (AUTHOR), Treadway, Jessica1 (AUTHOR), Green, Jonathon1 (AUTHOR), Koshman, Yevgeniya E2 (AUTHOR), Zafiratos, Mark1 (AUTHOR), Mittelstadt, Scott3 (AUTHOR), Blomme, Eric4 (AUTHOR), Foley, Charles M1 (AUTHOR) |
| Source: | Toxicological Sciences. May2025, Vol. 205 Issue 1, p233-244. 12p. |
| Database: | Environment Complete |
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| ISSN: | 10966080 |
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| DOI: | 10.1093/toxsci/kfaf021 |