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Lactate supports a metabolic-epigenetic link in macrophage polarization.

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Title: Lactate supports a metabolic-epigenetic link in macrophage polarization.
Authors: Noe JT; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Rendon BE; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Geller AE; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA., Conroy LR; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA., Morrissey SM; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA., Young LEA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA., Bruntz RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA., Kim EJ; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Wise-Mitchell A; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Barbosa de Souza Rizzo M; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Relich ER; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA., Baby BV; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Johnson LA; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA., Affronti HC; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., McMasters KM; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA., Clem BF; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA., Gentry MS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA., Yan J; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Sun RC; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA., Mitchell RA; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.
Source: Science advances [Sci Adv] 2021 Nov 12; Vol. 7 (46), pp. eabi8602. Date of Electronic Publication: 2021 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE; PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Noe+JT%22">Noe JT</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Rendon+BE%22">Rendon BE</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Geller+AE%22">Geller AE</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Conroy+LR%22">Conroy LR</searchLink>; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Morrissey+SM%22">Morrissey SM</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Young+LEA%22">Young LEA</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Bruntz+RC%22">Bruntz RC</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Kim+EJ%22">Kim EJ</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Wise-Mitchell+A%22">Wise-Mitchell A</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Barbosa+de+Souza+Rizzo+M%22">Barbosa de Souza Rizzo M</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Relich+ER%22">Relich ER</searchLink>; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Baby+BV%22">Baby BV</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+LA%22">Johnson LA</searchLink>; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA.<br /><searchLink fieldCode="AU" term="%22Affronti+HC%22">Affronti HC</searchLink>; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22McMasters+KM%22">McMasters KM</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Clem+BF%22">Clem BF</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Gentry+MS%22">Gentry MS</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.<br /><searchLink fieldCode="AU" term="%22Wellen+KE%22">Wellen KE</searchLink>; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sun+RC%22">Sun RC</searchLink>; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+RA%22">Mitchell RA</searchLink>; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2021 Nov 12; Vol. 7 (46), pp. eabi8602. <i>Date of Electronic Publication: </i>2021 Nov 12.
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