ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.
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| Title: | ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1. |
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| Authors: | Balmanno K; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Byrne DP; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Sale MJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Nassman N; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Eyers PA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K. |
| Source: | The Biochemical journal [Biochem J] 2023 May 15; Vol. 480 (9), pp. 587-605. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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