ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.

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Title: ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.
Authors: Stojanovic L; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland., Abbotts R; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland., Tripathi K; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland., Coon CM; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana., Rajendran S; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana., Abbasi Farid E; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana., Hostetter G; Van Andel Research Institute, Grand Rapids, Michigan., Guarnieri JW; Division of Human Genetics, Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Wallace DC; Division of Human Genetics, Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Division of Human Genetics, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Liu S; Department of Medical and Molecular Genetics, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana., Wan J; Department of Medical and Molecular Genetics, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana., Calendo G; Coriell Institute for Medical Research, Camden, New Jersey., Marker R; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland., Gohari Z; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland., Inayatullah MMA; University of Southern Denmark, Odense, Denmark., Tiwari VK; University of Southern Denmark, Odense, Denmark., Kader T; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts., Santagata S; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Drapkin R; Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania., Kommoss S; Institute for Health Informatics, Diakonie-Klinikum Schwäbisch Hall, Schwäbisch Hall, Germany.; Kliniken Essen-Mitte, Gynäkologie und Gynäkologische Onkologie, Essen, Germany., Pfisterer J; Department of Medicine, David Geffen School of Medicine, Los Angeles, California., Konecny GE; University of California Los Angeles, Los Angeles, California., Coopergard R; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota., Issa JJ; Coriell Institute for Medical Research, Camden, New Jersey., Winterhoff BJN; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health (OBGYN), University of Minesota, Minneapolis, Minnesota., Topper MJ; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Sandusky GE; Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana., Miller KD; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana.; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Baylin SB; Van Andel Research Institute, Grand Rapids, Michigan.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Nephew KP; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana., Rassool FV; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Source: Cancer research [Cancer Res] 2025 Apr 03; Vol. 85 (7), pp. 1183-1198.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Stojanovic+L%22">Stojanovic L</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Abbotts+R%22">Abbotts R</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Tripathi+K%22">Tripathi K</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Coon+CM%22">Coon CM</searchLink>; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana.<br /><searchLink fieldCode="AU" term="%22Rajendran+S%22">Rajendran S</searchLink>; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana.<br /><searchLink fieldCode="AU" term="%22Abbasi+Farid+E%22">Abbasi Farid E</searchLink>; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana.<br /><searchLink fieldCode="AU" term="%22Hostetter+G%22">Hostetter G</searchLink>; Van Andel Research Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Guarnieri+JW%22">Guarnieri JW</searchLink>; Division of Human Genetics, Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wallace+DC%22">Wallace DC</searchLink>; Division of Human Genetics, Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; 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University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Inayatullah+MMA%22">Inayatullah MMA</searchLink>; University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Tiwari+VK%22">Tiwari VK</searchLink>; University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Kader+T%22">Kader T</searchLink>; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Santagata+S%22">Santagata S</searchLink>; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Drapkin+R%22">Drapkin R</searchLink>; Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kommoss+S%22">Kommoss S</searchLink>; Institute for Health Informatics, Diakonie-Klinikum Schwäbisch Hall, Schwäbisch Hall, Germany.; Kliniken Essen-Mitte, Gynäkologie und Gynäkologische Onkologie, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Pfisterer+J%22">Pfisterer J</searchLink>; Department of Medicine, David Geffen School of Medicine, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Konecny+GE%22">Konecny GE</searchLink>; University of California Los Angeles, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Coopergard+R%22">Coopergard R</searchLink>; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Issa+JJ%22">Issa JJ</searchLink>; Coriell Institute for Medical Research, Camden, New Jersey.<br /><searchLink fieldCode="AU" term="%22Winterhoff+BJN%22">Winterhoff BJN</searchLink>; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health (OBGYN), University of Minesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Topper+MJ%22">Topper MJ</searchLink>; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Sandusky+GE%22">Sandusky GE</searchLink>; Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Miller+KD%22">Miller KD</searchLink>; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana.; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Baylin+SB%22">Baylin SB</searchLink>; Van Andel Research Institute, Grand Rapids, Michigan.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Nephew+KP%22">Nephew KP</searchLink>; Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, Indiana.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Rassool+FV%22">Rassool FV</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.; Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
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