Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
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| Title: | Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses. |
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| Authors: | Chang YH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Biomedical Translation Research Center, Academia Sinica, Taipei 115, Taiwan., Lee YC; Department of Nutrition Therapy, E-Da Cancer Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Dachang Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan., Chen SH; School of Nursing, Fooyin University, Kaohsiung 831, Taiwan., Fang SY; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Cheng TP; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Chi CH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan., Tsai KC; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan., Chen PJ; Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: ed113510@edah.org.tw., Hung HY; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: z10308005@email.ncku.edu.tw. |
| Source: | Biochemical pharmacology [Biochem Pharmacol] 2025 May; Vol. 235, pp. 116806. Date of Electronic Publication: 2025 Feb 14. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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