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Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages.

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Title: Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages.
Authors: Ke CJ; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Liu ST; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The School of Pharmacy, Fujian Medical University, Fuzhou, China., Qian YD; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The School of Pharmacy, Fujian Medical University, Fuzhou, China., You X; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Lin RF; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Lin CH; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Huang PF; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Lin WW; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Jul; Vol. 91 (7), pp. 1927-1936. Date of Electronic Publication: 2025 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages.
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  Data: <searchLink fieldCode="AU" term="%22Ke+CJ%22">Ke CJ</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+ST%22">Liu ST</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The School of Pharmacy, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Qian+YD%22">Qian YD</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The School of Pharmacy, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22You+X%22">You X</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+RF%22">Lin RF</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+PF%22">Huang PF</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+WW%22">Lin WW</searchLink>; Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Department of Pharmacy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2025 Jul; Vol. 91 (7), pp. 1927-1936. <i>Date of Electronic Publication: </i>2025 Feb 17.
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              Text: 2025 Jul
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