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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.

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Title: Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
Authors: Cregg J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Edwards AV; Revolution Medicines, Inc., Redwood City, California 94063, United States., Chang S; Revolution Medicines, Inc., Redwood City, California 94063, United States., Lee BJ; Revolution Medicines, Inc., Redwood City, California 94063, United States., Knox JE; Revolution Medicines, Inc., Redwood City, California 94063, United States., Tomlinson ACA; Revolution Medicines, Inc., Redwood City, California 94063, United States., Marquez A; Revolution Medicines, Inc., Redwood City, California 94063, United States., Liu Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Freilich R; Revolution Medicines, Inc., Redwood City, California 94063, United States., Aay N; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang L; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Flagella M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wildes D; Revolution Medicines, Inc., Redwood City, California 94063, United States., Smith JAM; Revolution Medicines, Inc., Redwood City, California 94063, United States., Singh M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Gill AL; Revolution Medicines, Inc., Redwood City, California 94063, United States., Koltun ES; Revolution Medicines, Inc., Redwood City, California 94063, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6064-6083. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
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  Data: <searchLink fieldCode="AU" term="%22Cregg+J%22">Cregg J</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Edwards+AV%22">Edwards AV</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Chang+S%22">Chang S</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Lee+BJ%22">Lee BJ</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Knox+JE%22">Knox JE</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Tomlinson+ACA%22">Tomlinson ACA</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Marquez+A%22">Marquez A</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Freilich+R%22">Freilich R</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Aay+N%22">Aay N</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Flagella+M%22">Flagella M</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Wildes+D%22">Wildes D</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Smith+JAM%22">Smith JAM</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Gill+AL%22">Gill AL</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.<br /><searchLink fieldCode="AU" term="%22Koltun+ES%22">Koltun ES</searchLink>; Revolution Medicines, Inc., Redwood City, California 94063, United States.
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