Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
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| Title: | Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. |
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| Authors: | Cregg J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Edwards AV; Revolution Medicines, Inc., Redwood City, California 94063, United States., Chang S; Revolution Medicines, Inc., Redwood City, California 94063, United States., Lee BJ; Revolution Medicines, Inc., Redwood City, California 94063, United States., Knox JE; Revolution Medicines, Inc., Redwood City, California 94063, United States., Tomlinson ACA; Revolution Medicines, Inc., Redwood City, California 94063, United States., Marquez A; Revolution Medicines, Inc., Redwood City, California 94063, United States., Liu Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Freilich R; Revolution Medicines, Inc., Redwood City, California 94063, United States., Aay N; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang L; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Flagella M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wildes D; Revolution Medicines, Inc., Redwood City, California 94063, United States., Smith JAM; Revolution Medicines, Inc., Redwood City, California 94063, United States., Singh M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Gill AL; Revolution Medicines, Inc., Redwood City, California 94063, United States., Koltun ES; Revolution Medicines, Inc., Redwood City, California 94063, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6064-6083. Date of Electronic Publication: 2025 Mar 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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