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Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine-induced adverse effects in an acute lymphoblastic leukemia patient-derived xenograft model.

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Title: Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine-induced adverse effects in an acute lymphoblastic leukemia patient-derived xenograft model.
Authors: Starobova H; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia., McCalmont H; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Shatunova S; Mater Research Institute, The University of Queensland South Brisbane Queensland Australia., Tay N; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia., Smith CM; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Robertson A; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia., Winkler I; Mater Research Institute, The University of Queensland South Brisbane Queensland Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Vetter I; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.; School of Pharmacy and Pharmaceutical Sciences The University of Queensland Woolloongabba Queensland Australia.
Source: HemaSphere [Hemasphere] 2025 Mar 18; Vol. 9 (3), pp. e70092. Date of Electronic Publication: 2025 Mar 18 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine-induced adverse effects in an acute lymphoblastic leukemia patient-derived xenograft model.
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  Data: <searchLink fieldCode="AU" term="%22Starobova+H%22">Starobova H</searchLink>; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.<br /><searchLink fieldCode="AU" term="%22McCalmont+H%22">McCalmont H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Shatunova+S%22">Shatunova S</searchLink>; Mater Research Institute, The University of Queensland South Brisbane Queensland Australia.<br /><searchLink fieldCode="AU" term="%22Tay+N%22">Tay N</searchLink>; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.<br /><searchLink fieldCode="AU" term="%22Smith+CM%22">Smith CM</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Robertson+A%22">Robertson A</searchLink>; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.; School of Chemistry and Molecular Biosciences The University of Queensland St Lucia Queensland Australia.<br /><searchLink fieldCode="AU" term="%22Winkler+I%22">Winkler I</searchLink>; Mater Research Institute, The University of Queensland South Brisbane Queensland Australia.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Vetter+I%22">Vetter I</searchLink>; Institute for Molecular Bioscience, The University of Queensland St Lucia Queensland Australia.; School of Pharmacy and Pharmaceutical Sciences The University of Queensland Woolloongabba Queensland Australia.
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  Data: <searchLink fieldCode="JN" term="%22101740619%22">HemaSphere</searchLink> [Hemasphere] 2025 Mar 18; Vol. 9 (3), pp. e70092. <i>Date of Electronic Publication: </i>2025 Mar 18 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101740619 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2572-9241 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225729241%22">25729241 </searchLink><i>NLM ISO Abbreviation: </i>Hemasphere <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Mar 18
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