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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.

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Title: Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.
Authors: Matuskova H; SOTIO Biotech a.s, Prague, Czech Republic., Marasek P; SOTIO Biotech a.s, Prague, Czech Republic., Mazhara V; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Simonova E; SOTIO Biotech a.s, Prague, Czech Republic., Kosinova L; SOTIO Biotech a.s, Prague, Czech Republic., Danek P; SOTIO Biotech a.s, Prague, Czech Republic., Danova K; SOTIO Biotech a.s, Prague, Czech Republic., Sajnerova K; SOTIO Biotech a.s, Prague, Czech Republic., Malatova I; SOTIO Biotech a.s, Prague, Czech Republic., Hrabankova K; SOTIO Biotech a.s, Prague, Czech Republic., Greco D; SOTIO Biotech a.s, Prague, Czech Republic., Martinec O; SOTIO Biotech a.s, Prague, Czech Republic., Fabisik M; SOTIO Biotech a.s, Prague, Czech Republic., Podzimkova N; SOTIO Biotech a.s, Prague, Czech Republic., Hladikova K; SOTIO Biotech a.s, Prague, Czech Republic., Behalova K; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Antosova Z; SOTIO Biotech a.s, Prague, Czech Republic., Sirova M; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Mikyskova R; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic., Reinis M; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic., Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic., Béchard D; Cytune Pharma S.A.S, Nantes, France., Moebius U; SOTIO Biotech a.s, Prague, Czech Republic., Palova Jelinkova L; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic., Spisek R; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic., Steegmaier M; SOTIO Biotech a.s, Prague, Czech Republic., Adkins I; SOTIO Biotech a.s, Prague, Czech Republic adkins@sotio.com.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Apr 17; Vol. 13 (4). Date of Electronic Publication: 2025 Apr 17.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.
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  Data: <searchLink fieldCode="AU" term="%22Matuskova+H%22">Matuskova H</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Marasek+P%22">Marasek P</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mazhara+V%22">Mazhara V</searchLink>; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Simonova+E%22">Simonova E</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kosinova+L%22">Kosinova L</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Danek+P%22">Danek P</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Danova+K%22">Danova K</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sajnerova+K%22">Sajnerova K</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Malatova+I%22">Malatova I</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hrabankova+K%22">Hrabankova K</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Greco+D%22">Greco D</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Martinec+O%22">Martinec O</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Fabisik+M%22">Fabisik M</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Podzimkova+N%22">Podzimkova N</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hladikova+K%22">Hladikova K</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Behalova+K%22">Behalova K</searchLink>; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Antosova+Z%22">Antosova Z</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sirova+M%22">Sirova M</searchLink>; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Mikyskova+R%22">Mikyskova R</searchLink>; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Reinis+M%22">Reinis M</searchLink>; Laboratory of Immunological and Tumor models, Institute of Molecular Genetics Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kovar+M%22">Kovar M</searchLink>; Laboratory of Tumor Immunology, Institute of Microbiology Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Béchard+D%22">Béchard D</searchLink>; Cytune Pharma S.A.S, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Moebius+U%22">Moebius U</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Palova+Jelinkova+L%22">Palova Jelinkova L</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Spisek+R%22">Spisek R</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Steegmaier+M%22">Steegmaier M</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Adkins+I%22">Adkins I</searchLink>; SOTIO Biotech a.s, Prague, Czech Republic adkins@sotio.com.; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czech Republic.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2025 Apr 17; Vol. 13 (4). <i>Date of Electronic Publication: </i>2025 Apr 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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