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The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.

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Title: The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.
Authors: Issa NT; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida., Shen T; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Vizurraga A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Pronin A; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Henry T; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Wang Q; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Kwarcinski FE; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Schürer S; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida., Badiavas E; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida., Tall GG; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: gregtall@umich.edu., Slepak VZ; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: vslepak@med.miami.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2025 Aug; Vol. 107 (8), pp. 100059. Date of Electronic Publication: 2025 Jul 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release.
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  Data: <searchLink fieldCode="AU" term="%22Issa+NT%22">Issa NT</searchLink>; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Shen+T%22">Shen T</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Vizurraga+A%22">Vizurraga A</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Pronin+A%22">Pronin A</searchLink>; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Henry+T%22">Henry T</searchLink>; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Kwarcinski+FE%22">Kwarcinski FE</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Schürer+S%22">Schürer S</searchLink>; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Badiavas+E%22">Badiavas E</searchLink>; Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Tall+GG%22">Tall GG</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: gregtall@umich.edu.<br /><searchLink fieldCode="AU" term="%22Slepak+VZ%22">Slepak VZ</searchLink>; Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: vslepak@med.miami.edu.
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  Data: <searchLink fieldCode="JN" term="%220035623%22">Molecular pharmacology</searchLink> [Mol Pharmacol] 2025 Aug; Vol. 107 (8), pp. 100059. <i>Date of Electronic Publication: </i>2025 Jul 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Pharmacology+and+Experimental+Therapeutics%22">American Society for Pharmacology and Experimental Therapeutics </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0035623 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0111 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220026895X%22">0026895X </searchLink><i>NLM ISO Abbreviation: </i>Mol Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.molpha.2025.100059
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