Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins.
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| Title: | Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins. |
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| Authors: | Wade J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Štrancar N; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Siebenhaar S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Jansen T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Meier EPW; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Bjørn SP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Nguyen GTT; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Lomonte B; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica., Gutiérrez JM; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica., Sørensen CV; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.; BioInnovation Institute, Copenhagen, Denmark., Loeffler JR; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Paul A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Tulika T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Arnsdorf J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Schoffelen S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Lundquist EVS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Sørensen J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Voldborg BG; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Bohn MF; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Morth JP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark. |
| Source: | MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2553624. Date of Electronic Publication: 2025 Sep 11. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40936197 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wade+J%22">Wade J</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Štrancar+N%22">Štrancar N</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Fernández-Quintero+ML%22">Fernández-Quintero ML</searchLink>; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Siebenhaar+S%22">Siebenhaar S</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Jansen+T%22">Jansen T</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Meier+EPW%22">Meier EPW</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Jenkins+TP%22">Jenkins TP</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjørn+SP%22">Bjørn SP</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Nguyen+GTT%22">Nguyen GTT</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Lomonte+B%22">Lomonte B</searchLink>; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica.<br /><searchLink fieldCode="AU" term="%22Gutiérrez+JM%22">Gutiérrez JM</searchLink>; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica.<br /><searchLink fieldCode="AU" term="%22Sørensen+CV%22">Sørensen CV</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.; BioInnovation Institute, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Loeffler+JR%22">Loeffler JR</searchLink>; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Paul+A%22">Paul A</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Tulika+T%22">Tulika T</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Arnsdorf+J%22">Arnsdorf J</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Schoffelen+S%22">Schoffelen S</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Lundquist+EVS%22">Lundquist EVS</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+J%22">Sørensen J</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Voldborg+BG%22">Voldborg BG</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Bohn+MF%22">Bohn MF</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Rivera-de-Torre+E%22">Rivera-de-Torre E</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Morth+JP%22">Morth JP</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.<br /><searchLink fieldCode="AU" term="%22Laustsen+AH%22">Laustsen AH</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101479829%22">MAbs</searchLink> [MAbs] 2025 Dec; Vol. 17 (1), pp. 2553624. <i>Date of Electronic Publication: </i>2025 Sep 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101479829 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1942-0870 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219420862%22">19420862 </searchLink><i>NLM ISO Abbreviation: </i>MAbs <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40936197 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/19420862.2025.2553624 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2553624 Titles: – TitleFull: Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wade J – PersonEntity: Name: NameFull: Štrancar N – PersonEntity: Name: NameFull: Fernández-Quintero ML – PersonEntity: Name: NameFull: Siebenhaar S – PersonEntity: Name: NameFull: Jansen T – PersonEntity: Name: NameFull: Meier EPW – PersonEntity: Name: NameFull: Jenkins TP – PersonEntity: Name: NameFull: Bjørn SP – PersonEntity: Name: NameFull: Nguyen GTT – PersonEntity: Name: NameFull: Lomonte B – PersonEntity: Name: NameFull: Gutiérrez JM – PersonEntity: Name: NameFull: Sørensen CV – PersonEntity: Name: NameFull: Loeffler JR – PersonEntity: Name: NameFull: Paul A – PersonEntity: Name: NameFull: Tulika T – PersonEntity: Name: NameFull: Arnsdorf J – PersonEntity: Name: NameFull: Schoffelen S – PersonEntity: Name: NameFull: Lundquist EVS – PersonEntity: Name: NameFull: Sørensen J – PersonEntity: Name: NameFull: Ward AB – PersonEntity: Name: NameFull: Voldborg BG – PersonEntity: Name: NameFull: Bohn MF – PersonEntity: Name: NameFull: Rivera-de-Torre E – PersonEntity: Name: NameFull: Morth JP – PersonEntity: Name: NameFull: Laustsen AH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2025 Dec Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1942-0870 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: MAbs Type: main |
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