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Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids.

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Title: Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids.
Authors: Li LL; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Sun CJ; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Mo XT; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Xing Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhang T; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhang H; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhao N; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zeng XF; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China., Wang SS; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China., Meng YY; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. mengyan2293@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. mengyan2293@whu.edu.cn., Xie SY; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. yangsai1995@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. yangsai1995@whu.edu.cn., Deng W; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. vivideng1982@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. vivideng1982@whu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Feb; Vol. 47 (2), pp. 328-343. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids.
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  Data: <searchLink fieldCode="AU" term="%22Li+LL%22">Li LL</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Sun+CJ%22">Sun CJ</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Mo+XT%22">Mo XT</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Zhao+N%22">Zhao N</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Zeng+XF%22">Zeng XF</searchLink>; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Wang+SS%22">Wang SS</searchLink>; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China.<br /><searchLink fieldCode="AU" term="%22Meng+YY%22">Meng YY</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. mengyan2293@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. mengyan2293@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xie+SY%22">Xie SY</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. yangsai1995@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. yangsai1995@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Deng+W%22">Deng W</searchLink>; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. vivideng1982@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. vivideng1982@whu.edu.cn.
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              Text: 2026 Feb
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