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Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.

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Title: Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.
Authors: Sheng T; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Sundar R; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Medicine (Medical Oncology), Yale University, New Haven, Connecticut, USA., Srivastava S; Department of Medicine, National University Hospital, Singapore., Ong X; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Tay ST; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ma H; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Uchihara T; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Lian BSX; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Hagihara T; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Kong MS; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Xu C; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ho SWT; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Huang KK; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Tan ALK; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ng MSW; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Toh J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Ng CSY; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Nasca V; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Pircher CC; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Randon G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Giordano S; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Corso S; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Lum JHY; Department of Pathology, National University Hospital, Singapore., Teh M; Department of Pathology, National University Hospital, Singapore., Zhao JJ; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Department of Medicine, National University Hospital, Singapore., So JBY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Surgery, National University of Singapore, Singapore.; Department of Surgery, University Surgical Cluster, National University Health System, Singapore.; NUS Centre for Cancer Research, National University of Singapore, Singapore., Sabella G; Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Prabhakar S; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Lee J; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea., Yong WP; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Ng MCH; Division of Medical Oncology, National Cancer Centre, Singapore., Shitara K; Department of Gastrointestinal Surgery, National Cancer Center Hospital East, Kashiwa, Japan., Gasparello J; Department of Medicine, University of Padua, Padua, Italy., Fassan M; Department of Medicine, University of Padua, Padua, Italy.; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy., Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg., Tan P; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singhealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore.
Source: Gut [Gut] 2026 Mar 06; Vol. 75 (4), pp. 733-747. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.
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  Data: <searchLink fieldCode="AU" term="%22Sheng+T%22">Sheng T</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Sundar+R%22">Sundar R</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Medicine (Medical Oncology), Yale University, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Srivastava+S%22">Srivastava S</searchLink>; Department of Medicine, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+X%22">Ong X</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+ST%22">Tay ST</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Uchihara+T%22">Uchihara T</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lian+BSX%22">Lian BSX</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Hagihara+T%22">Hagihara T</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Kong+MS%22">Kong MS</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+SWT%22">Ho SWT</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+KK%22">Huang KK</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+ALK%22">Tan ALK</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+MSW%22">Ng MSW</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+J%22">Toh J</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+CSY%22">Ng CSY</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Nasca+V%22">Nasca V</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pircher+CC%22">Pircher CC</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Randon+G%22">Randon G</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Corso+S%22">Corso S</searchLink>; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Lum+JHY%22">Lum JHY</searchLink>; Department of Pathology, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Teh+M%22">Teh M</searchLink>; Department of Pathology, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+JJ%22">Zhao JJ</searchLink>; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Department of Medicine, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22So+JBY%22">So JBY</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Surgery, National University of Singapore, Singapore.; Department of Surgery, University Surgical Cluster, National University Health System, Singapore.; NUS Centre for Cancer Research, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sabella+G%22">Sabella G</searchLink>; Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prabhakar+S%22">Prabhakar S</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea.<br /><searchLink fieldCode="AU" term="%22Yong+WP%22">Yong WP</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+MCH%22">Ng MCH</searchLink>; Division of Medical Oncology, National Cancer Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Shitara+K%22">Shitara K</searchLink>; Department of Gastrointestinal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Gasparello+J%22">Gasparello J</searchLink>; Department of Medicine, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Fassan+M%22">Fassan M</searchLink>; Department of Medicine, University of Padua, Padua, Italy.; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Pietrantonio+F%22">Pietrantonio F</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singhealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore.
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  Data: <searchLink fieldCode="JN" term="%222985108R%22">Gut</searchLink> [Gut] 2026 Mar 06; Vol. 75 (4), pp. 733-747. <i>Date of Electronic Publication: </i>2026 Mar 06.
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