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Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.

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Title: Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.
Authors: Hirschfield GM; The Autoimmune and Rare Liver Disease Programme, Division of Gastroenterology and Hepatology, University Health Network, Toronto General Hospital, Toronto, ON, Canada. Electronic address: gideon.hirschfield@uhn.ca., Bowlus CL; Division of Gastroenterology and Hepatology, University of California Davis School of Medicine, Sacramento, CA, USA., Jones DEJ; Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK., Kremer AE; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Mayo MJ; University of Texas Southwestern Medical School, Dallas, TX, USA., Tanaka A; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan., Andreone P; Medicina Interna Metabolica, Baggiovara Hospital, Azienda Ospedaliero-Universitaria di Modena and Università di Modena e Reggio Emilia, Modena, Italy., Jia J; Liver Research Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Jin Q; Department of Hepatology, The First Hospital of Jilin University, Changchun, China., Macías-Rodríguez RU; Division of Hepatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Cobitz AR; GSK, Collegeville, PA, USA., Currie BM; GSK, Collegeville, PA, USA., Gorey C; GSK, London, UK., Lazic I; GSK, London, UK., Podmore D; GSK, London, UK., Ribeiro A; GSK, Madrid, Spain., Shannon JB; GSK, Durham, NC, USA., Swift B; GSK, Durham, NC, USA., McLaughlin MM; GSK, Collegeville, PA, USA., Levy C; Division of Digestive Health and Liver Diseases and Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA.
Corporate Authors: GLISTEN Study Group
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jan; Vol. 11 (1), pp. 22-33. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Hirschfield+GM%22">Hirschfield GM</searchLink>; The Autoimmune and Rare Liver Disease Programme, Division of Gastroenterology and Hepatology, University Health Network, Toronto General Hospital, Toronto, ON, Canada. Electronic address: gideon.hirschfield@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Bowlus+CL%22">Bowlus CL</searchLink>; Division of Gastroenterology and Hepatology, University of California Davis School of Medicine, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DEJ%22">Jones DEJ</searchLink>; Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Kremer+AE%22">Kremer AE</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mayo+MJ%22">Mayo MJ</searchLink>; University of Texas Southwestern Medical School, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+A%22">Tanaka A</searchLink>; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Andreone+P%22">Andreone P</searchLink>; Medicina Interna Metabolica, Baggiovara Hospital, Azienda Ospedaliero-Universitaria di Modena and Università di Modena e Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Jia+J%22">Jia J</searchLink>; Liver Research Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jin+Q%22">Jin Q</searchLink>; Department of Hepatology, The First Hospital of Jilin University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Macías-Rodríguez+RU%22">Macías-Rodríguez RU</searchLink>; Division of Hepatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Cobitz+AR%22">Cobitz AR</searchLink>; GSK, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Currie+BM%22">Currie BM</searchLink>; GSK, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gorey+C%22">Gorey C</searchLink>; GSK, London, UK.<br /><searchLink fieldCode="AU" term="%22Lazic+I%22">Lazic I</searchLink>; GSK, London, UK.<br /><searchLink fieldCode="AU" term="%22Podmore+D%22">Podmore D</searchLink>; GSK, London, UK.<br /><searchLink fieldCode="AU" term="%22Ribeiro+A%22">Ribeiro A</searchLink>; GSK, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Shannon+JB%22">Shannon JB</searchLink>; GSK, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Swift+B%22">Swift B</searchLink>; GSK, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McLaughlin+MM%22">McLaughlin MM</searchLink>; GSK, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Levy+C%22">Levy C</searchLink>; Division of Digestive Health and Liver Diseases and Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA.
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  Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2026 Jan; Vol. 11 (1), pp. 22-33. <i>Date of Electronic Publication: </i>2025 Oct 28.
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  Data: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101690683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2468-1253 (Electronic) <i>NLM ISO Abbreviation: </i>Lancet Gastroenterol Hepatol <i>Subsets: </i>MEDLINE
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