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A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.

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Title: A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.
Authors: Shojaei Jeshvaghani Z; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., de Vries MH; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands., van Es JH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Collen LV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Kotlarz D; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany., Sveen M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Comella PH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., Snapper SB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States., Klein C; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany., Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Mokry M; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CX, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands., Kuijk E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Utrecht 3584 CT, The Netherlands., Nieuwenhuis E; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Princess Maximá Center for Pediatric Oncology, Utrecht 3584 CS, The Netherlands.
Source: Inflammatory bowel diseases [Inflamm Bowel Dis] 2026 Jan 01; Vol. 32 (1), pp. 9-24.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Shojaei+Jeshvaghani+Z%22">Shojaei Jeshvaghani Z</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Argmann+C%22">Argmann C</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.<br /><searchLink fieldCode="AU" term="%22de+Vries+MH%22">de Vries MH</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Es+JH%22">van Es JH</searchLink>; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Collen+LV%22">Collen LV</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States.<br /><searchLink fieldCode="AU" term="%22Kotlarz+D%22">Kotlarz D</searchLink>; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany.<br /><searchLink fieldCode="AU" term="%22Sveen+M%22">Sveen M</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States.<br /><searchLink fieldCode="AU" term="%22Comella+PH%22">Comella PH</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.<br /><searchLink fieldCode="AU" term="%22Snapper+SB%22">Snapper SB</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Munich 80337, Germany.<br /><searchLink fieldCode="AU" term="%22Schadt+EE%22">Schadt EE</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.<br /><searchLink fieldCode="AU" term="%22Clevers+H%22">Clevers H</searchLink>; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Oncode Institute, UMC Utrecht, Utrecht 3584 CT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mokry+M%22">Mokry M</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CX, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuijk+E%22">Kuijk E</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Department of Pediatrics, Lab of Cellular Disease Models, Regenerative Medicine Center Utrecht, UMC Utrecht, Utrecht 3584 CT, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nieuwenhuis+E%22">Nieuwenhuis E</searchLink>; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, Utrecht 3584 EA, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center, Utrecht University, Utrecht 3584 CT, The Netherlands.; Princess Maximá Center for Pediatric Oncology, Utrecht 3584 CS, The Netherlands.
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