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Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.

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Title: Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.
Authors: Leitner BP; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Fosam AE; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Lee WD; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540., Zilinger K; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Nakandakari SCBR; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Zhang X; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Gaspar RC; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Zhu W; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Perry CJ; Department of Internal Medicine, Yale University, New Haven, CT 06510., Rabinowitz JD; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540.; Department of Molecular Biology, Princeton University, Princeton, NJ 06540., Perry RJ; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 09; Vol. 122 (49), pp. e2508707122. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.
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  Data: <searchLink fieldCode="AU" term="%22Leitner+BP%22">Leitner BP</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Fosam+AE%22">Fosam AE</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Lee+WD%22">Lee WD</searchLink>; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540.<br /><searchLink fieldCode="AU" term="%22Zilinger+K%22">Zilinger K</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Nakandakari+SCBR%22">Nakandakari SCBR</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Gaspar+RC%22">Gaspar RC</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Perry+CJ%22">Perry CJ</searchLink>; Department of Internal Medicine, Yale University, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+JD%22">Rabinowitz JD</searchLink>; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540.; Department of Molecular Biology, Princeton University, Princeton, NJ 06540.<br /><searchLink fieldCode="AU" term="%22Perry+RJ%22">Perry RJ</searchLink>; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Dec 09; Vol. 122 (49), pp. e2508707122. <i>Date of Electronic Publication: </i>2025 Dec 01.
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