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Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model.

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Title: Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model.
Authors: Nieznanska A; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Statkiewicz M; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Sandowska-Markiewicz Z; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Unrug-Bielawska K; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Majewska A; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Kocik-Krol J; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Czepiel M; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland., Galuszka-Bulaga A; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland., Mikula M; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Ostrowski J; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Holak TA; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Skalniak L; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. Electronic address: lukasz.skalniak@uj.edu.pl.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118868. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Nieznanska+A%22">Nieznanska A</searchLink>; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Statkiewicz+M%22">Statkiewicz M</searchLink>; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland.<br /><searchLink fieldCode="AU" term="%22Sandowska-Markiewicz+Z%22">Sandowska-Markiewicz Z</searchLink>; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland.<br /><searchLink fieldCode="AU" term="%22Unrug-Bielawska+K%22">Unrug-Bielawska K</searchLink>; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland.<br /><searchLink fieldCode="AU" term="%22Majewska+A%22">Majewska A</searchLink>; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Kocik-Krol+J%22">Kocik-Krol J</searchLink>; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Czepiel+M%22">Czepiel M</searchLink>; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland.<br /><searchLink fieldCode="AU" term="%22Galuszka-Bulaga+A%22">Galuszka-Bulaga A</searchLink>; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland.<br /><searchLink fieldCode="AU" term="%22Mikula+M%22">Mikula M</searchLink>; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland.<br /><searchLink fieldCode="AU" term="%22Ostrowski+J%22">Ostrowski J</searchLink>; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland.<br /><searchLink fieldCode="AU" term="%22Holak+TA%22">Holak TA</searchLink>; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland.<br /><searchLink fieldCode="AU" term="%22Skalniak+L%22">Skalniak L</searchLink>; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. Electronic address: lukasz.skalniak@uj.edu.pl.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118868. <i>Date of Electronic Publication: </i>2025 Dec 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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