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CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

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Title: CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.
Authors: Fisher RJ; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Park K; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Lee K; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Pinjusic K; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Vanasse A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Ennis CS; Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Farokh P; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Ficaro SB; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Marto JA; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Jiang H; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Nam E; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Stransky S; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA., Duke-Cohan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Akinci MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Geethadevi A; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA., Raabe E; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA., Fiszbein A; Department of Biology, Boston University, Boston, Massachusetts, USA., Demehri S; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA., Hicks CW; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Cole PA; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Alani RM; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2025 Dec 09; Vol. 11 (2). Date of Electronic Publication: 2025 Dec 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Fisher+RJ%22">Fisher RJ</searchLink>; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Park+K%22">Park K</searchLink>; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pinjusic+K%22">Pinjusic K</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vanasse+A%22">Vanasse A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ennis+CS%22">Ennis CS</searchLink>; Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Farokh+P%22">Farokh P</searchLink>; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ficaro+SB%22">Ficaro SB</searchLink>; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Marto+JA%22">Marto JA</searchLink>; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Nam+E%22">Nam E</searchLink>; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Stransky+S%22">Stransky S</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Duke-Cohan+J%22">Duke-Cohan J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Akinci+MA%22">Akinci MA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Geethadevi+A%22">Geethadevi A</searchLink>; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Raabe+E%22">Raabe E</searchLink>; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fiszbein+A%22">Fiszbein A</searchLink>; Department of Biology, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Demehri+S%22">Demehri S</searchLink>; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sidoli+S%22">Sidoli S</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Hicks+CW%22">Hicks CW</searchLink>; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Keskin+DB%22">Keskin DB</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Wu+CJ%22">Wu CJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cole+PA%22">Cole PA</searchLink>; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Alani+RM%22">Alani RM</searchLink>; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
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