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Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.

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Title: Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.
Authors: Böck D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch., Tidecks L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Wilhelm M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., ElGrawani W; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland., Duss S; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Vena D; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Reuss AM; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Kissling L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ranucci M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Privitera M; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Polzer LK; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany., Economides AE; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Ioannidi EI; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mendes R; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Weber Y; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Leonardi J; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Mumenthaler J; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Villiger E; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Goutagny R; University of Strasbourg, CNRS, LNCA UMR 7364, Strasbourg, France., Mathis C; University of Strasbourg, CNRS, LNCA UMR 7364, Strasbourg, France., Schmidheini L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Rothgangl T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Janjuha S; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland., Bohacek J; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Sych Y; Institute of Cellular and Integrative Neuroscience, CNRS UPR3212, University of Strasbourg, Strasbourg, France., Aguzzi A; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Winterer J; Laboratory of Systems Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Kompotis K; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch.
Source: Nature communications [Nat Commun] 2025 Dec 09; Vol. 16 (1), pp. 10973. Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Prime editing of the β<subscript>1</subscript> adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Böck+D%22">Böck D</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.<br /><searchLink fieldCode="AU" term="%22Tidecks+L%22">Tidecks L</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wilhelm+M%22">Wilhelm M</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22ElGrawani+W%22">ElGrawani W</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Duss+S%22">Duss S</searchLink>; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Trevisan+C%22">Trevisan C</searchLink>; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vena+D%22">Vena D</searchLink>; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reuss+AM%22">Reuss AM</searchLink>; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kissling+L%22">Kissling L</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ranucci+M%22">Ranucci M</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Privitera+M%22">Privitera M</searchLink>; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Polzer+LK%22">Polzer LK</searchLink>; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Economides+AE%22">Economides AE</searchLink>; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ioannidi+EI%22">Ioannidi EI</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mendes+R%22">Mendes R</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Weber+Y%22">Weber Y</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Leonardi+J%22">Leonardi J</searchLink>; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mumenthaler+J%22">Mumenthaler J</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Villiger+E%22">Villiger E</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goutagny+R%22">Goutagny R</searchLink>; 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Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sych+Y%22">Sych Y</searchLink>; Institute of Cellular and Integrative Neuroscience, CNRS UPR3212, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Aguzzi+A%22">Aguzzi A</searchLink>; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Winterer+J%22">Winterer J</searchLink>; Laboratory of Systems Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kompotis+K%22">Kompotis K</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schwank+G%22">Schwank G</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch.
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