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First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent.

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Title: First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent.
Authors: Patwardhan RS; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Radiobiology & Omics Lab, Radiological Research Unit, Bhabha Atomic Research Centre Facility, Kharghar, Navi Mumbai 410210, India., Rizvi ZA; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India., Gota V; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India. Electronic address: vgota@actrec.gov.in., Checker R; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Singh B; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Maurya DK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Pal D; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Ramani N; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Kumar BK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India., Purohit V; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India., Mathapati BS; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India., Mullick J; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India., Ghanty TK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Gupta S; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India., Joshi M; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India., Madki S; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India., Awasthi A; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India. Electronic address: aawasthi@thsti.res.in., Sandur SK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: sskumar@barc.gov.in., Sharma D; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: dsharma@barc.gov.in.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jan; Vol. 150, pp. 157689. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
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  Data: First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent.
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  Data: <searchLink fieldCode="AU" term="%22Patwardhan+RS%22">Patwardhan RS</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Radiobiology & Omics Lab, Radiological Research Unit, Bhabha Atomic Research Centre Facility, Kharghar, Navi Mumbai 410210, India.<br /><searchLink fieldCode="AU" term="%22Rizvi+ZA%22">Rizvi ZA</searchLink>; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India.<br /><searchLink fieldCode="AU" term="%22Gota+V%22">Gota V</searchLink>; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India. Electronic address: vgota@actrec.gov.in.<br /><searchLink fieldCode="AU" term="%22Checker+R%22">Checker R</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Singh+B%22">Singh B</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Maurya+DK%22">Maurya DK</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Pal+D%22">Pal D</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Ramani+N%22">Ramani N</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Kumar+BK%22">Kumar BK</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.<br /><searchLink fieldCode="AU" term="%22Purohit+V%22">Purohit V</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.<br /><searchLink fieldCode="AU" term="%22Mathapati+BS%22">Mathapati BS</searchLink>; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India.<br /><searchLink fieldCode="AU" term="%22Mullick+J%22">Mullick J</searchLink>; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India.<br /><searchLink fieldCode="AU" term="%22Ghanty+TK%22">Ghanty TK</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India.<br /><searchLink fieldCode="AU" term="%22Joshi+M%22">Joshi M</searchLink>; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India.<br /><searchLink fieldCode="AU" term="%22Madki+S%22">Madki S</searchLink>; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India.<br /><searchLink fieldCode="AU" term="%22Awasthi+A%22">Awasthi A</searchLink>; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India. Electronic address: aawasthi@thsti.res.in.<br /><searchLink fieldCode="AU" term="%22Sandur+SK%22">Sandur SK</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: sskumar@barc.gov.in.<br /><searchLink fieldCode="AU" term="%22Sharma+D%22">Sharma D</searchLink>; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: dsharma@barc.gov.in.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.phymed.2025.157689
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              Text: 2026 Jan
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