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Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity.

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Title: Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity.
Authors: Newman DM; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Andersen CL; Oncology R&D, AstraZeneca, Waltham, MA, USA., Cluse LA; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Newbold A; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Fraser P; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Legg BWC; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia., Xu LK; Oncology R&D, AstraZeneca, Waltham, MA, USA., Mele DA; Oncology R&D, AstraZeneca, Waltham, MA, USA. deanna.mele@astrazeneca.com., Johnstone RW; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. ricky.johnstone@petermac.org.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia. ricky.johnstone@petermac.org.
Source: Cell death & disease [Cell Death Dis] 2026 Jan 06; Vol. 17 (1), pp. 177. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity.
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  Data: <searchLink fieldCode="AU" term="%22Newman+DM%22">Newman DM</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Oncology R&D, AstraZeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cluse+LA%22">Cluse LA</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Newbold+A%22">Newbold A</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Fraser+P%22">Fraser P</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Legg+BWC%22">Legg BWC</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Xu+LK%22">Xu LK</searchLink>; Oncology R&D, AstraZeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mele+DA%22">Mele DA</searchLink>; Oncology R&D, AstraZeneca, Waltham, MA, USA. deanna.mele@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Johnstone+RW%22">Johnstone RW</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. ricky.johnstone@petermac.org.; Gene Regulation Laboratory, Peter MacCallum Cancer Centre, Grattan Street, 3000, Melbourne, Australia. ricky.johnstone@petermac.org.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Jan 06; Vol. 17 (1), pp. 177. <i>Date of Electronic Publication: </i>2026 Jan 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2026 Jan 06
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