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MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.

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Title: MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
Authors: Gudiksen A; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: anders.gudiksen@bio.ku.dk., Hansen CC; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., van der Stede T; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium., Daugaard AH; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Schmidt JH; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Ringholm S; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Merimi M; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Al-Obaidi FR; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Kristoffersen AT; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Zole E; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark., Regenberg B; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark., Kjøbsted R; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Wojtaszewski J; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Hellsten Y; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Pilegaard H; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: hpilegaard@bio.ku.dk.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Mar 16; Vol. 246, pp. 682-696. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
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  Data: MOTS-c improves intrinsic muscle mitochondrial bioenergetic health and efficiency in a PGC-1α/AMPK-dependent manner.
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  Data: <searchLink fieldCode="AU" term="%22Gudiksen+A%22">Gudiksen A</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: anders.gudiksen@bio.ku.dk.<br /><searchLink fieldCode="AU" term="%22Hansen+CC%22">Hansen CC</searchLink>; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22van+der+Stede+T%22">van der Stede T</searchLink>; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Daugaard+AH%22">Daugaard AH</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schmidt+JH%22">Schmidt JH</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ringholm+S%22">Ringholm S</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Merimi+M%22">Merimi M</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Al-Obaidi+FR%22">Al-Obaidi FR</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kristoffersen+AT%22">Kristoffersen AT</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Zole+E%22">Zole E</searchLink>; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Regenberg+B%22">Regenberg B</searchLink>; Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kjøbsted+R%22">Kjøbsted R</searchLink>; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Wojtaszewski+J%22">Wojtaszewski J</searchLink>; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hellsten+Y%22">Hellsten Y</searchLink>; The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pilegaard+H%22">Pilegaard H</searchLink>; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: hpilegaard@bio.ku.dk.
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