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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

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Title: CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.
Authors: Watterson A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Picco G; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Veninga V; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Samarakoon Y; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK., Cattaneo CM; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Vieira SF; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Karakoc E; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Bhosle S; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK., Battaglia TW; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., Consonni S; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Halim TYF; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK., Voest EE; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands., Garnett MJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK., Coelho MA; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK. Electronic address: matthew.coelho@sanger.ac.uk.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jan 20; Vol. 7 (1), pp. 102565.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.
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  Data: <searchLink fieldCode="AU" term="%22Watterson+A%22">Watterson A</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Picco+G%22">Picco G</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Veninga+V%22">Veninga V</searchLink>; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Samarakoon+Y%22">Samarakoon Y</searchLink>; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cattaneo+CM%22">Cattaneo CM</searchLink>; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vieira+SF%22">Vieira SF</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Karakoc+E%22">Karakoc E</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Bhosle+S%22">Bhosle S</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Battaglia+TW%22">Battaglia TW</searchLink>; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Consonni+S%22">Consonni S</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Voest+EE%22">Voest EE</searchLink>; Department of Immunology and Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Garnett+MJ%22">Garnett MJ</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Coelho+MA%22">Coelho MA</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Open Targets, Cambridgeshire, UK. Electronic address: matthew.coelho@sanger.ac.uk.
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              Text: 2026 Jan 20
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