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The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer.

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Title: The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer.
Authors: Schultz L; Division of Pediatric Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford Medicine, Stanford, CA, USA. lioras@stanford.edu., McNerney K; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Lamble AJ; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Calkoen FG; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Baruchel A; Department of Pediatric Hematology, Hôpital Universitaire Robert Debré, Assistance Publique-Hôpitaux de Paris and Université Paris Cité, Paris, France., Ceppi F; Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department of Woman-Mother-Child, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland., Curran KJ; Department of Pediatrics, Stem Cell Transplantation and Cellular Therapies Service, Memorial Sloan Kettering, New York, NY, USA., Gore L; Children's Hospital Colorado and the University of Colorado School of Medicine, Aurora, CO, USA., Lamb M; Division of Hematology, Oncology, Blood and Bone Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA., Maude SL; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pulsipher MA; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA., Qayed M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA., Ramakrishna S; Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA., Rheingold SR; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rossig C; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany., Silbert SK; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Steineck A; MACC Fund Center for Cancer and Blood Disorders, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Summers C; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Capitini CM; Department of Pediatrics and Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bhojwani D; Division of Hematology-Oncology, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gardner RA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Ghorashian S; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.; Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, UK., Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. nirali.shah@nih.gov.
Source: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2026 Apr; Vol. 23 (4), pp. 260-278. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500077 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4782 (Electronic) Linking ISSN: 17594774 NLM ISO Abbreviation: Nat Rev Clin Oncol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schultz+L%22">Schultz L</searchLink>; Division of Pediatric Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford Medicine, Stanford, CA, USA. lioras@stanford.edu.<br /><searchLink fieldCode="AU" term="%22McNerney+K%22">McNerney K</searchLink>; Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lamble+AJ%22">Lamble AJ</searchLink>; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Calkoen+FG%22">Calkoen FG</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Baruchel+A%22">Baruchel A</searchLink>; Department of Pediatric Hematology, Hôpital Universitaire Robert Debré, Assistance Publique-Hôpitaux de Paris and Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ceppi+F%22">Ceppi F</searchLink>; Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department of Woman-Mother-Child, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Curran+KJ%22">Curran KJ</searchLink>; Department of Pediatrics, Stem Cell Transplantation and Cellular Therapies Service, Memorial Sloan Kettering, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gore+L%22">Gore L</searchLink>; Children's Hospital Colorado and the University of Colorado School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lamb+M%22">Lamb M</searchLink>; Division of Hematology, Oncology, Blood and Bone Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Maude+SL%22">Maude SL</searchLink>; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pulsipher+MA%22">Pulsipher MA</searchLink>; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Qayed+M%22">Qayed M</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ramakrishna+S%22">Ramakrishna S</searchLink>; Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rheingold+SR%22">Rheingold SR</searchLink>; Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rossig+C%22">Rossig C</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Silbert+SK%22">Silbert SK</searchLink>; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Steineck+A%22">Steineck A</searchLink>; MACC Fund Center for Cancer and Blood Disorders, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Summers+C%22">Summers C</searchLink>; Department of Pediatrics, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Capitini+CM%22">Capitini CM</searchLink>; Department of Pediatrics and Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Bhojwani+D%22">Bhojwani D</searchLink>; Division of Hematology-Oncology, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+RA%22">Gardner RA</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ghorashian+S%22">Ghorashian S</searchLink>; Department of Haematology, Great Ormond Street Hospital for Children, London, UK.; Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Shah+NN%22">Shah NN</searchLink>; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. nirali.shah@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101500077%22">Nature reviews. Clinical oncology</searchLink> [Nat Rev Clin Oncol] 2026 Apr; Vol. 23 (4), pp. 260-278. <i>Date of Electronic Publication: </i>2026 Jan 23.
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