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Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance.

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Title: Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance.
Authors: Garcia-Robledo JE; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Hematología y Oncología (CIHO), IDC Instituto de Cáncer Hemato Oncólogos, Cali, Colombia., Cabrera-Salcedo S; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Brandauer AM; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Romano F; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Rengifo-Martinez J; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Clinical Research Center, Rio Grande Urology, El Paso, TX, United States., Toro-Pedroza A; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Victoria JS; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia., Rios-Serna LJ; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (CIRAT), Universidad Icesi, Cali, Colombia., Loukanov A; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Chemistry and Materials Science, National Institute of Technology, Gunma College, Maebashi, Japan., Cardona AF; Department of Oncology, Centro de Tratamiento e Investigación Sobre Cáncer Luis Carlos Sarmiento Angulo (CTIC), Bogotá, Colombia., Genovese P; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States., Baena JC; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Hematology/Oncology, Fundación Valle del Lili, Cali, Colombia.
Source: Frontiers in oncology [Front Oncol] 2026 Jan 09; Vol. 15, pp. 1698442. Date of Electronic Publication: 2026 Jan 09 (Print Publication: 2025).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Garcia-Robledo+JE%22">Garcia-Robledo JE</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Hematología y Oncología (CIHO), IDC Instituto de Cáncer Hemato Oncólogos, Cali, Colombia.<br /><searchLink fieldCode="AU" term="%22Cabrera-Salcedo+S%22">Cabrera-Salcedo S</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.<br /><searchLink fieldCode="AU" term="%22Brandauer+AM%22">Brandauer AM</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Romano+F%22">Romano F</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Rengifo-Martinez+J%22">Rengifo-Martinez J</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Clinical Research Center, Rio Grande Urology, El Paso, TX, United States.<br /><searchLink fieldCode="AU" term="%22Toro-Pedroza+A%22">Toro-Pedroza A</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.<br /><searchLink fieldCode="AU" term="%22Victoria+JS%22">Victoria JS</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.<br /><searchLink fieldCode="AU" term="%22Rios-Serna+LJ%22">Rios-Serna LJ</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (CIRAT), Universidad Icesi, Cali, Colombia.<br /><searchLink fieldCode="AU" term="%22Loukanov+A%22">Loukanov A</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Chemistry and Materials Science, National Institute of Technology, Gunma College, Maebashi, Japan.<br /><searchLink fieldCode="AU" term="%22Cardona+AF%22">Cardona AF</searchLink>; Department of Oncology, Centro de Tratamiento e Investigación Sobre Cáncer Luis Carlos Sarmiento Angulo (CTIC), Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Genovese+P%22">Genovese P</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Harvard Medical School, Boston, MA, United States.; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Baena+JC%22">Baena JC</searchLink>; LiliCAR-T Group, Fundación Valle del Lili, Cali, Colombia.; Department of Hematology/Oncology, Fundación Valle del Lili, Cali, Colombia.
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