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Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.

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Title: Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.
Authors: Bai Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Lei H; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Gou S; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Lan J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Cai D; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Zheng X; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China., Shen J; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Chen Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Zhao Y; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Deng S; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Wu X; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Li M; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China., Xiao Z; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn., Zhang Y; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China. 13795747769@163.com., Du F; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.
Source: Archives of pharmacal research [Arch Pharm Res] 2026 Jan; Vol. 49 (1), pp. 61-100. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Lei+H%22">Lei H</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Gou+S%22">Gou S</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Lan+J%22">Lan J</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Cai+D%22">Cai D</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Deng+S%22">Deng S</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Xiao+Z%22">Xiao Z</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. zhangangxiao@swmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Oncology, Luzhou People's Hospital, Luzhou, 646000, Sichuan, China. 13795747769@163.com.<br /><searchLink fieldCode="AU" term="%22Du+F%22">Du F</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.; South Sichuan Institute of Translational Medicine, Luzhou, 646000, Sichuan, China. dufukuan@swmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228000036%22">Archives of pharmacal research</searchLink> [Arch Pharm Res] 2026 Jan; Vol. 49 (1), pp. 61-100. <i>Date of Electronic Publication: </i>2026 Feb 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pharmaceutical+Society+of+Korea%22">Pharmaceutical Society of Korea </searchLink><i>Country of Publication: </i>Korea (South) <i>NLM ID: </i>8000036 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1976-3786 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202536269%22">02536269 </searchLink><i>NLM ISO Abbreviation: </i>Arch Pharm Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s12272-026-01595-z
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      – Code: eng
        Text: English
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        StartPage: 61
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      – TitleFull: Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics.
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              Text: 2026 Jan
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