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WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.

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Title: WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.
Authors: Nirschl CJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Subramanian KK; Werewolf Therapeutics Inc., Watertown, Massachusetts., Brodkin HR; Werewolf Therapeutics Inc., Watertown, Massachusetts., Domonkos C; Werewolf Therapeutics Inc., Watertown, Massachusetts., Dwyer CJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Hicklin DJ; Werewolf Therapeutics Inc., Watertown, Massachusetts., Isaacs R; Werewolf Therapeutics Inc., Watertown, Massachusetts., Ismail NS; Werewolf Therapeutics Inc., Watertown, Massachusetts., LePrevost J; Werewolf Therapeutics Inc., Watertown, Massachusetts., Lewis Y; Werewolf Therapeutics Inc., Watertown, Massachusetts., Morris K; Werewolf Therapeutics Inc., Watertown, Massachusetts., Seidel-Dugan C; Werewolf Therapeutics Inc., Watertown, Massachusetts., Steuert Z; Werewolf Therapeutics Inc., Watertown, Massachusetts., Sullivan JM; Werewolf Therapeutics Inc., Watertown, Massachusetts., Chopra SS; Werewolf Therapeutics Inc., Watertown, Massachusetts., Salmeron A; Werewolf Therapeutics Inc., Watertown, Massachusetts., Winston WM; Werewolf Therapeutics Inc., Watertown, Massachusetts.
Source: Cancer immunology research [Cancer Immunol Res] 2026 Mar 04; Vol. 14 (3), pp. 434-449.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.
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  Data: <searchLink fieldCode="AU" term="%22Nirschl+CJ%22">Nirschl CJ</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Subramanian+KK%22">Subramanian KK</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Brodkin+HR%22">Brodkin HR</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Domonkos+C%22">Domonkos C</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Dwyer+CJ%22">Dwyer CJ</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hicklin+DJ%22">Hicklin DJ</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Isaacs+R%22">Isaacs R</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ismail+NS%22">Ismail NS</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22LePrevost+J%22">LePrevost J</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lewis+Y%22">Lewis Y</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Morris+K%22">Morris K</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Seidel-Dugan+C%22">Seidel-Dugan C</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Steuert+Z%22">Steuert Z</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sullivan+JM%22">Sullivan JM</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chopra+SS%22">Chopra SS</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Salmeron+A%22">Salmeron A</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Winston+WM%22">Winston WM</searchLink>; Werewolf Therapeutics Inc., Watertown, Massachusetts.
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  Data: <searchLink fieldCode="JN" term="%22101614637%22">Cancer immunology research</searchLink> [Cancer Immunol Res] 2026 Mar 04; Vol. 14 (3), pp. 434-449.
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              Text: 2026 Mar 04
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