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Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.

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Title: Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.
Authors: Zhou J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Yang Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liu S; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Chen J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liao H; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liang W; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Zhang Z; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Wang Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Liu Y; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Zhang H; Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, China., Jiang H; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Lin W; The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China., Qu J; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China., Barger SW; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Wu S; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. wszlab@wmu.edu.cn.
Source: Communications biology [Commun Biol] 2026 Feb 25; Vol. 9 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liao+H%22">Liao H</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liang+W%22">Liang W</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Zhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink>; The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Qu+J%22">Qu J</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Barger+SW%22">Barger SW</searchLink>; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. wszlab@wmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2026 Feb 25; Vol. 9 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+UK%22">Nature Publishing Group UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101719179 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2399-3642 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223993642%22">23993642 </searchLink><i>NLM ISO Abbreviation: </i>Commun Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s42003-026-09772-y
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              Text: 2026 Feb 25
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