Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial.
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| Title: | Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial. |
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| Authors: | Dipper A; Academic Respiratory Unit, University of Bristol, Bristol, UK., Sundaralingam A; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Imperial College Healthcare NHS Trust, London, UK. Electronic address: anand.sundaralingam@ndm.ox.ac.uk., Hedley E; Imperial College Healthcare NHS Trust, London, UK., Gudur S; Lancashire Teaching Hospitals, Preston, UK., Mills J; Lancashire Teaching Hospitals, Preston, UK., Sowden S; Lancashire Teaching Hospitals, Preston, UK., Corcoran JP; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK., Daneshvar C; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK., Craig C; Lung Cancer and Thoracic Surgery Directorate, Wythenshawe Hospital, Manchester NHS Foundation Trust, Manchester, UK., Moore AJ; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Milne A; Academic Respiratory Unit, University of Bristol, Bristol, UK., Clive A; North Bristol NHS Trust, Bristol, UK., Bhatnagar R; Academic Respiratory Unit, University of Bristol, Bristol, UK; North Bristol NHS Trust, Bristol, UK; Odense Respiratory Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Roberts ME; Sherwood Forest Hospitals NHS Trust, Sutton-in-Ashfield, UK., Nagarajan T; Macclesfield General Hospital, Macclesfield, UK., Kutubudin F; Macclesfield General Hospital, Macclesfield, UK., Wassal H; Macclesfield General Hospital, Macclesfield, UK., Aboushehata M; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Iftikhar S; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Haris M; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Abraham M; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., Sudhir R; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., Panchal RK; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., de Fonseka D; Academic Respiratory Department, Sheffield Teaching Hospitals, Sheffield, UK., Bedawi EO; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Iqbal B; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK., Addala D; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK., Wrightson J; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Menzies D; Glan Clwyd Hospital, Bodelwyddan, UK., Ratushnyak S; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK., Luengo-Fernandez R; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK., Miller RF; Institute for Global Health, University College London, London, UK., White P; School of Data and Mathematics, University of the West of England, Bristol, UK., Munavvar M; Lancashire Teaching Hospitals, Preston, UK; School of Medicine, University of Central Lancashire, Preston, UK; Lancashire Teaching Hospitals, Preston, UK., Rahman NM; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Oxford National Institute for Health and Care Research Biomedical Research Centre, Oxford, UK., Maskell N; Academic Respiratory Unit, University of Bristol, Bristol, UK. |
| Source: | The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Apr; Vol. 14 (4), pp. 341-349. Date of Electronic Publication: 2026 Feb 25. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41763237 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Dipper+A%22">Dipper A</searchLink>; Academic Respiratory Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Sundaralingam+A%22">Sundaralingam A</searchLink>; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Imperial College Healthcare NHS Trust, London, UK. Electronic address: anand.sundaralingam@ndm.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hedley+E%22">Hedley E</searchLink>; Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Gudur+S%22">Gudur S</searchLink>; Lancashire Teaching Hospitals, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Mills+J%22">Mills J</searchLink>; Lancashire Teaching Hospitals, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Sowden+S%22">Sowden S</searchLink>; Lancashire Teaching Hospitals, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Corcoran+JP%22">Corcoran JP</searchLink>; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK.<br /><searchLink fieldCode="AU" term="%22Daneshvar+C%22">Daneshvar C</searchLink>; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK.<br /><searchLink fieldCode="AU" term="%22Craig+C%22">Craig C</searchLink>; Lung Cancer and Thoracic Surgery Directorate, Wythenshawe Hospital, Manchester NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Moore+AJ%22">Moore AJ</searchLink>; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Milne+A%22">Milne A</searchLink>; Academic Respiratory Unit, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Clive+A%22">Clive A</searchLink>; North Bristol NHS Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Bhatnagar+R%22">Bhatnagar R</searchLink>; Academic Respiratory Unit, University of Bristol, Bristol, UK; North Bristol NHS Trust, Bristol, UK; Odense Respiratory Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Roberts+ME%22">Roberts ME</searchLink>; Sherwood Forest Hospitals NHS Trust, Sutton-in-Ashfield, UK.<br /><searchLink fieldCode="AU" term="%22Nagarajan+T%22">Nagarajan T</searchLink>; Macclesfield General Hospital, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Kutubudin+F%22">Kutubudin F</searchLink>; Macclesfield General Hospital, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Wassal+H%22">Wassal H</searchLink>; Macclesfield General Hospital, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Aboushehata+M%22">Aboushehata M</searchLink>; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.<br /><searchLink fieldCode="AU" term="%22Iftikhar+S%22">Iftikhar S</searchLink>; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.<br /><searchLink fieldCode="AU" term="%22Haris+M%22">Haris M</searchLink>; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.<br /><searchLink fieldCode="AU" term="%22Abraham+M%22">Abraham M</searchLink>; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Sudhir+R%22">Sudhir R</searchLink>; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Panchal+RK%22">Panchal RK</searchLink>; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22de+Fonseka+D%22">de Fonseka D</searchLink>; Academic Respiratory Department, Sheffield Teaching Hospitals, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Bedawi+EO%22">Bedawi EO</searchLink>; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Iqbal+B%22">Iqbal B</searchLink>; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Addala+D%22">Addala D</searchLink>; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wrightson+J%22">Wrightson J</searchLink>; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Menzies+D%22">Menzies D</searchLink>; Glan Clwyd Hospital, Bodelwyddan, UK.<br /><searchLink fieldCode="AU" term="%22Ratushnyak+S%22">Ratushnyak S</searchLink>; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Luengo-Fernandez+R%22">Luengo-Fernandez R</searchLink>; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Miller+RF%22">Miller RF</searchLink>; Institute for Global Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22White+P%22">White P</searchLink>; School of Data and Mathematics, University of the West of England, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Munavvar+M%22">Munavvar M</searchLink>; Lancashire Teaching Hospitals, Preston, UK; School of Medicine, University of Central Lancashire, Preston, UK; Lancashire Teaching Hospitals, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Rahman+NM%22">Rahman NM</searchLink>; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Oxford National Institute for Health and Care Research Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maskell+N%22">Maskell N</searchLink>; Academic Respiratory Unit, University of Bristol, Bristol, UK. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2026 Apr; Vol. 14 (4), pp. 341-349. <i>Date of Electronic Publication: </i>2026 Feb 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101605555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2619 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132600%22">22132600 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Respir Med <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2213-2600(25)00409-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 341 Titles: – TitleFull: Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dipper A – PersonEntity: Name: NameFull: Sundaralingam A – PersonEntity: Name: NameFull: Hedley E – PersonEntity: Name: NameFull: Gudur S – PersonEntity: Name: NameFull: Mills J – PersonEntity: Name: NameFull: Sowden S – PersonEntity: Name: NameFull: Corcoran JP – PersonEntity: Name: NameFull: Daneshvar C – PersonEntity: Name: NameFull: Craig C – PersonEntity: Name: NameFull: Moore AJ – PersonEntity: Name: NameFull: Milne A – PersonEntity: Name: NameFull: Clive A – PersonEntity: Name: NameFull: Bhatnagar R – PersonEntity: Name: NameFull: Roberts ME – PersonEntity: Name: NameFull: Nagarajan T – PersonEntity: Name: NameFull: Kutubudin F – PersonEntity: Name: NameFull: Wassal H – PersonEntity: Name: NameFull: Aboushehata M – PersonEntity: Name: NameFull: Iftikhar S – PersonEntity: Name: NameFull: Haris M – PersonEntity: Name: NameFull: Abraham M – PersonEntity: Name: NameFull: Sudhir R – PersonEntity: Name: NameFull: Panchal RK – PersonEntity: Name: NameFull: de Fonseka D – PersonEntity: Name: NameFull: Bedawi EO – PersonEntity: Name: NameFull: Iqbal B – PersonEntity: Name: NameFull: Addala D – PersonEntity: Name: NameFull: Wrightson J – PersonEntity: Name: NameFull: Menzies D – PersonEntity: Name: NameFull: Ratushnyak S – PersonEntity: Name: NameFull: Luengo-Fernandez R – PersonEntity: Name: NameFull: Miller RF – PersonEntity: Name: NameFull: White P – PersonEntity: Name: NameFull: Munavvar M – PersonEntity: Name: NameFull: Rahman NM – PersonEntity: Name: NameFull: Maskell N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2213-2619 Numbering: – Type: volume Value: 14 – Type: issue Value: 4 Titles: – TitleFull: The Lancet. Respiratory medicine Type: main |
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