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Single-cell epigenetic landscape, microenvironment interactions, and gene regulatory modules of non-functioning pituitary adenomas.

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Title: Single-cell epigenetic landscape, microenvironment interactions, and gene regulatory modules of non-functioning pituitary adenomas.
Authors: Zhang Z; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cheng WS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Taniguchi-Ponciano K; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Marrero-Rodríguez D; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Smith GR; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pincas H; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sagendorf TJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA., Mendelev N; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Strupinsky G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ge Y; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zamojski M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chen X; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA., Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Park CY; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Andoniadou CL; Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK; Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Turgeon JL; Department of Internal Medicine, University of California, Davis, Davis, CA, USA., Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Troyanskaya OG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA., Mercado M; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: stuart.sealfon@mssm.edu., Ruf-Zamojski F; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: frederique.ruf-zamojski@csmc.edu.
Source: Cell systems [Cell Syst] 2026 Apr 15; Vol. 17 (4), pp. 101532. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+WS%22">Cheng WS</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Taniguchi-Ponciano+K%22">Taniguchi-Ponciano K</searchLink>; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Marrero-Rodríguez+D%22">Marrero-Rodríguez D</searchLink>; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Smith+GR%22">Smith GR</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Pincas+H%22">Pincas H</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Sagendorf+TJ%22">Sagendorf TJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.<br /><searchLink fieldCode="AU" term="%22Mendelev+N%22">Mendelev N</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Strupinsky+G%22">Strupinsky G</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Ge+Y%22">Ge Y</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Zamojski+M%22">Zamojski M</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Amper+MAS%22">Amper MAS</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Park+CY%22">Park CY</searchLink>; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.<br /><searchLink fieldCode="AU" term="%22Nair+VD%22">Nair VD</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Andoniadou+CL%22">Andoniadou CL</searchLink>; Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK; Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Turgeon+JL%22">Turgeon JL</searchLink>; Department of Internal Medicine, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zaslavsky+E%22">Zaslavsky E</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Troyanskaya+OG%22">Troyanskaya OG</searchLink>; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Mercado+M%22">Mercado M</searchLink>; Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Sealfon+SC%22">Sealfon SC</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: stuart.sealfon@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Ruf-Zamojski+F%22">Ruf-Zamojski F</searchLink>; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: frederique.ruf-zamojski@csmc.edu.
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