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PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion.

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Title: PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion.
Authors: Celada L; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.; Fundación Idonial, Gijón, Spain., Cubiella T; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., San-Juan-Guardado J; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Suárez-Priede Á; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Gómez-Suárez N; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain., Salerno L; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Murias E; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain., Da Silva Torres M; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain., Weiner JA; Department of Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA., Herrada-Manchón H; Fundación Idonial, Gijón, Spain., Fernández MA; Fundación Idonial, Gijón, Spain., Chiara MD; Health Research Institute of the Principado de Asturias, Oviedo, Spain. mdchiara.uo@uniovi.es.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain. mdchiara.uo@uniovi.es.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 26; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α activation, lipid metabolism rewiring, and ferroptosis evasion.
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  Data: <searchLink fieldCode="AU" term="%22Celada+L%22">Celada L</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.; Fundación Idonial, Gijón, Spain.<br /><searchLink fieldCode="AU" term="%22Cubiella+T%22">Cubiella T</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22San-Juan-Guardado+J%22">San-Juan-Guardado J</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Suárez-Priede+Á%22">Suárez-Priede Á</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Suárez+N%22">Gómez-Suárez N</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Salerno+L%22">Salerno L</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Murias+E%22">Murias E</searchLink>; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Da+Silva+Torres+M%22">Da Silva Torres M</searchLink>; Radiological Service, Hospital Universitario Central de Asturias, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Weiner+JA%22">Weiner JA</searchLink>; Department of Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Herrada-Manchón+H%22">Herrada-Manchón H</searchLink>; Fundación Idonial, Gijón, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+MA%22">Fernández MA</searchLink>; Fundación Idonial, Gijón, Spain.<br /><searchLink fieldCode="AU" term="%22Chiara+MD%22">Chiara MD</searchLink>; Health Research Institute of the Principado de Asturias, Oviedo, Spain. mdchiara.uo@uniovi.es.; Institute of Oncology of the Principado de Asturias, University of Oviedo, Oviedo, Spain. mdchiara.uo@uniovi.es.
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