Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis.
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| Title: | Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis. |
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| Authors: | Wrønding T; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Vomstein K; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lundgaard AT; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., DeLong K; Freya Biosciences Aps, Copenhagen, Denmark., Mollerup S; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark., Mortensen B; Freya Biosciences Aps, Copenhagen, Denmark., Bosma EF; Freya Biosciences Aps, Copenhagen, Denmark., Hellerung AM; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Engel EV; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Wiil KD; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Heintz JE; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Halkjær SI; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Hugerth LW; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Hartwig TS; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., Petersen AM; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Thomsen AB; Freya Biosciences Aps, Copenhagen, Denmark., Westergaard D; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark., la Cour Freiesleben N; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Westh H; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., van Hylckama Vlieg JET; Freya Biosciences Aps, Copenhagen, Denmark., Ensign LM; Freya Biosciences Aps, Copenhagen, Denmark; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Infectious Diseases, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Nielsen HS; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: henriette.svarre.nielsen@regionh.dk. |
| Source: | The Lancet. Microbe [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101294. Date of Electronic Publication: 2026 Mar 26. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41905375 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wrønding+T%22">Wrønding T</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Vomstein+K%22">Vomstein K</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lundgaard+AT%22">Lundgaard AT</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22DeLong+K%22">DeLong K</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Mollerup+S%22">Mollerup S</searchLink>; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+B%22">Mortensen B</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bosma+EF%22">Bosma EF</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hellerung+AM%22">Hellerung AM</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Engel+EV%22">Engel EV</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Wiil+KD%22">Wiil KD</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Heintz+JE%22">Heintz JE</searchLink>; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Halkjær+SI%22">Halkjær SI</searchLink>; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Hugerth+LW%22">Hugerth LW</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Hartwig+TS%22">Hartwig TS</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+AM%22">Petersen AM</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Thomsen+AB%22">Thomsen AB</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Westergaard+D%22">Westergaard D</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22la+Cour+Freiesleben+N%22">la Cour Freiesleben N</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Westh+H%22">Westh H</searchLink>; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Gastrounit, Medical Section, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22van+Hylckama+Vlieg+JET%22">van Hylckama Vlieg JET</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ensign+LM%22">Ensign LM</searchLink>; Freya Biosciences Aps, Copenhagen, Denmark; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Infectious Diseases, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nielsen+HS%22">Nielsen HS</searchLink>; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: henriette.svarre.nielsen@regionh.dk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101769019%22">The Lancet. Microbe</searchLink> [Lancet Microbe] 2026 Apr; Vol. 7 (4), pp. 101294. <i>Date of Electronic Publication: </i>2026 Mar 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101769019 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-5247 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226665247%22">26665247 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Microbe <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41905375 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lanmic.2025.101294 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 101294 Titles: – TitleFull: Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wrønding T – PersonEntity: Name: NameFull: Vomstein K – PersonEntity: Name: NameFull: Lundgaard AT – PersonEntity: Name: NameFull: DeLong K – PersonEntity: Name: NameFull: Mollerup S – PersonEntity: Name: NameFull: Mortensen B – PersonEntity: Name: NameFull: Bosma EF – PersonEntity: Name: NameFull: Hellerung AM – PersonEntity: Name: NameFull: Engel EV – PersonEntity: Name: NameFull: Wiil KD – PersonEntity: Name: NameFull: Heintz JE – PersonEntity: Name: NameFull: Halkjær SI – PersonEntity: Name: NameFull: Hugerth LW – PersonEntity: Name: NameFull: Hartwig TS – PersonEntity: Name: NameFull: Petersen AM – PersonEntity: Name: NameFull: Thomsen AB – PersonEntity: Name: NameFull: Westergaard D – PersonEntity: Name: NameFull: la Cour Freiesleben N – PersonEntity: Name: NameFull: Westh H – PersonEntity: Name: NameFull: van Hylckama Vlieg JET – PersonEntity: Name: NameFull: Ensign LM – PersonEntity: Name: NameFull: Nielsen HS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2666-5247 Numbering: – Type: volume Value: 7 – Type: issue Value: 4 Titles: – TitleFull: The Lancet. Microbe Type: main |
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