Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury.
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| Title: | Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury. |
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| Authors: | Chen Z; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Xie J; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Wu C; School of Medicine, Nankai University, Tianjin, China., Ye K; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China., Chen Y; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Song Y; Department of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Ma H; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China., Wu J; Laboratory Animal Research Center, Xiamen University, Xiameng, 361000, China., Chen L; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn., Xu Y; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. xuyanfang99@hotmail.com.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Apr 27; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42045152 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; School of Medicine, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Ye+K%22">Ye K</searchLink>; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Department of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Laboratory Animal Research Center, Xiamen University, Xiameng, 361000, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.; Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China. xuyanfang99@hotmail.com.; Central Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Apr 27; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Apr 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42045152 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-026-08794-y Languages: – Code: eng Text: English Titles: – TitleFull: Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen Z – PersonEntity: Name: NameFull: Xie J – PersonEntity: Name: NameFull: Wu C – PersonEntity: Name: NameFull: Ye K – PersonEntity: Name: NameFull: Chen Y – PersonEntity: Name: NameFull: Song Y – PersonEntity: Name: NameFull: Ma H – PersonEntity: Name: NameFull: Wu J – PersonEntity: Name: NameFull: Chen L – PersonEntity: Name: NameFull: Xu Y IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 04 Text: 2026 Apr 27 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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