RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy.
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| Title: | RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy. |
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| Authors: | Rogge M; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Fischer J; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Jakobi T; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona, College of Medicine, Phoenix, USA., Loewenthal Z; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Gupta P; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Jürgensen L; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany., Frey N; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany., Sandmann C; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Völkers M; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120, Heidelberg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany. |
| Source: | Journal of molecular and cellular cardiology plus [J Mol Cell Cardiol Plus] 2026 Apr 16; Vol. 16, pp. 100847. Date of Electronic Publication: 2026 Apr 16 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918470779706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-9761 (Electronic) Linking ISSN: 27729761 NLM ISO Abbreviation: J Mol Cell Cardiol Plus Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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