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Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.

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Title: Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.
Authors: Labrousse P; 35 Gatehouse Drive, Waltham, MA, 02451, USA. paul.labrousse@astrazeneca.com., Russell H; 35 Gatehouse Drive, Waltham, MA, 02451, USA., Stetson D; 35 Gatehouse Drive, Waltham, MA, 02451, USA., Powalowska-Pickton PK; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Anton KA; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Litovchenko M; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Lowy-Gallego E; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Lovell A; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Hackinger S; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Stolarek-Januszkiewicz M; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Balmforth BW; Biofidelity Ltd, Cambridge, CB4 0WN, UK., Hadfield J; AstraZeneca, Cambridge, CB2 0AA, UK.
Source: Scientific reports [Sci Rep] 2026 Jun 13. Date of Electronic Publication: 2026 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.
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  Data: <searchLink fieldCode="AU" term="%22Labrousse+P%22">Labrousse P</searchLink>; 35 Gatehouse Drive, Waltham, MA, 02451, USA. paul.labrousse@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Russell+H%22">Russell H</searchLink>; 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Stetson+D%22">Stetson D</searchLink>; 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Powalowska-Pickton+PK%22">Powalowska-Pickton PK</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Anton+KA%22">Anton KA</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Litovchenko+M%22">Litovchenko M</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Lowy-Gallego+E%22">Lowy-Gallego E</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Lovell+A%22">Lovell A</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Hackinger+S%22">Hackinger S</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Stolarek-Januszkiewicz+M%22">Stolarek-Januszkiewicz M</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Balmforth+BW%22">Balmforth BW</searchLink>; Biofidelity Ltd, Cambridge, CB4 0WN, UK.<br /><searchLink fieldCode="AU" term="%22Hadfield+J%22">Hadfield J</searchLink>; AstraZeneca, Cambridge, CB2 0AA, UK.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 13. <i>Date of Electronic Publication: </i>2026 Jun 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41598-026-57421-5
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      – TitleFull: Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.
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              Text: 2026 Jun 13
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