LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.

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Title: LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.
Authors: Ramage DE; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Wieske LHE; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Crowe C; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Christensen JB; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., von Wilmowski TA; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK., Bannister Z; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Grant DW; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK., Nakasone MA; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Haubrich K; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Dorward M; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Tchasovnikarova IA; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK., Weekes MP; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK., Matheson NJ; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK., Bayin NS; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Ciulli A; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK., Timms RT; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK. Electronic address: rtt20@cam.ac.uk.
Source: Molecular cell [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2828-2842.e12. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.
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  Data: <searchLink fieldCode="AU" term="%22Ramage+DE%22">Ramage DE</searchLink>; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wieske+LHE%22">Wieske LHE</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Crowe+C%22">Crowe C</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Christensen+JB%22">Christensen JB</searchLink>; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22von+Wilmowski+TA%22">von Wilmowski TA</searchLink>; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bannister+Z%22">Bannister Z</searchLink>; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Grant+DW%22">Grant DW</searchLink>; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Nakasone+MA%22">Nakasone MA</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Haubrich+K%22">Haubrich K</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Dorward+M%22">Dorward M</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Tchasovnikarova+IA%22">Tchasovnikarova IA</searchLink>; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Weekes+MP%22">Weekes MP</searchLink>; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Matheson+NJ%22">Matheson NJ</searchLink>; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK; NHS Blood and Transplant, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bayin+NS%22">Bayin NS</searchLink>; The Gurdon Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ciulli+A%22">Ciulli A</searchLink>; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Timms+RT%22">Timms RT</searchLink>; Cambridge Institute for Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, UK. Electronic address: rtt20@cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2828-2842.e12. <i>Date of Electronic Publication: </i>2026 Jun 19.
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              Text: 2026 Jul 16
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