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Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

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Title: Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.
Authors: da Silva AMP; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil. anderson.matheuss@ufpe.br., Tudella GCN; Department of Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil., Gonçalves OR; Department of Medicine, Federal University of Piauí, Teresina, PI, Brazil., Ribeiro FV; Department of Medicine, Faculty of Medicine, Barão de Mauá University Center, Ribeirão Preto, SP, Brazil., Pereira MAOM; Department of Medicine, State University of Piauí, Teresina, PI, Brazil., do Nascimento MDVS; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil., Nogueira BV; Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA., Santos DH; Department of Neurology, University of São Paulo, São Paulo, SP, Brazil., de Gobbi Porto FH; Department and Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Duarte FS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil., Perry G; Department of Neurosciences, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA., de Souza Franco E; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil., de Sousa Maia MB; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil.
Source: Drugs [Drugs] 2026 Jul; Vol. 86 (7), pp. 1103-1119. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.
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  Data: <searchLink fieldCode="AU" term="%22da+Silva+AMP%22">da Silva AMP</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil. anderson.matheuss@ufpe.br.<br /><searchLink fieldCode="AU" term="%22Tudella+GCN%22">Tudella GCN</searchLink>; Department of Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+OR%22">Gonçalves OR</searchLink>; Department of Medicine, Federal University of Piauí, Teresina, PI, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro+FV%22">Ribeiro FV</searchLink>; Department of Medicine, Faculty of Medicine, Barão de Mauá University Center, Ribeirão Preto, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+MAOM%22">Pereira MAOM</searchLink>; Department of Medicine, State University of Piauí, Teresina, PI, Brazil.<br /><searchLink fieldCode="AU" term="%22do+Nascimento+MDVS%22">do Nascimento MDVS</searchLink>; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22Nogueira+BV%22">Nogueira BV</searchLink>; Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Santos+DH%22">Santos DH</searchLink>; Department of Neurology, University of São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Gobbi+Porto+FH%22">de Gobbi Porto FH</searchLink>; Department and Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Høilund-Carlsen+PF%22">Høilund-Carlsen PF</searchLink>; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Duarte+FS%22">Duarte FS</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.<br /><searchLink fieldCode="AU" term="%22Perry+G%22">Perry G</searchLink>; Department of Neurosciences, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22de+Souza+Franco+E%22">de Souza Franco E</searchLink>; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Maia+MB%22">de Sousa Maia MB</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.; Center for Medical Sciences, Graduate Program in Translational Health, Federal University of Pernambuco, Recife, PE, Brazil.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>7600076 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1950 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200126667%22">00126667 </searchLink><i>NLM ISO Abbreviation: </i>Drugs <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul
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